Patel Neel H, Ferretti Mark, Phillips John L
Department of Urology, New York Medical College, Valhalla, NY, USA.
Case Rep Urol. 2017;2017:7083451. doi: 10.1155/2017/7083451. Epub 2017 May 18.
Hyper IgE Syndrome (HIES) is an immunodeficiency disorder characterized by increased serum levels of IgE, eczema, and recurrent cutaneous and pulmonary infections. In this report, we present, to our knowledge, the first documented case of renal cell carcinoma (RCC) found in a patient with HIES. The patient received infectious disease clearance prior to obtaining a partial nephrectomy which revealed clear cell histology. Both HIES and RCC have an immunological basis for their pathophysiology and may involve common pathways. Further studies may provide insight into any possible link and clinicians should be mindful of immunocompromised patients who present with risk factors for genitourinary malignancy.
高免疫球蛋白E综合征（HIES）是一种免疫缺陷疾病，其特征为血清免疫球蛋白E水平升高、湿疹以及反复的皮肤和肺部感染。在本报告中，据我们所知，我们呈现了首例在HIES患者中发现肾细胞癌（RCC）的记录病例。该患者在接受部分肾切除术之前进行了传染病筛查，术后病理显示为透明细胞组织学类型。HIES和RCC在病理生理学上均有免疫学基础，且可能涉及共同途径。进一步的研究可能会揭示二者之间的潜在联系，临床医生应关注存在泌尿生殖系统恶性肿瘤危险因素的免疫功能低下患者。
