Anderson Ethan M, Self David W
Department of Psychiatry, The Seay Center for Basic and Applied Research in Psychiatric Illness, UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, USA 75390-9070.
Curr Opin Behav Sci. 2017 Feb;13:117-123. doi: 10.1016/j.cobeha.2016.11.013. Epub 2016 Dec 3.
Many reports show that repeated cocaine administration increases dendritic spine density in medium spiny neurons of the nucleus accumbens, but there is less agreement regarding the persistence of these changes. In this review we examine these discrepancies by systematically categorizing papers that measured cocaine-induced changes in accumbal spine density. We compare published reports based on withdrawal time, short versus long duration of cocaine administration, environmental pairing with cocaine, and core/shell subregion specificity. Together, these studies suggest that cocaine exposure induces rapid and dose-dependent increases in spine density in accumbens neurons that may play a role in the maintenance of cocaine use and vulnerability to early relapse, but are not a factor in behavioral changes associated with longer abstinence.
许多报告表明，反复给予可卡因会增加伏隔核中中等棘状神经元的树突棘密度，但对于这些变化的持续性，人们的意见不太一致。在本综述中，我们通过系统地分类测量可卡因诱导的伏隔核棘密度变化的论文来研究这些差异。我们根据戒断时间、可卡因给药的短期与长期、与可卡因的环境配对以及核心/壳亚区域特异性来比较已发表的报告。这些研究共同表明，接触可卡因会导致伏隔核神经元的棘密度迅速且剂量依赖性增加，这可能在维持可卡因使用和早期复发易感性方面发挥作用，但不是与更长时间禁欲相关的行为变化的一个因素。
