Qi Chaorong, Hu Xiaohan, Jiang Huanfeng
Key Lab of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, P. R. China.
Chem Commun (Camb). 2017 Jul 13;53(57):7994-7997. doi: 10.1039/c7cc03384b.
A copper-mediated direct C-H cyanation of (hetero)arenes with ethyl (ethoxymethylene)cyanoacetate as a safe cyanating agent has been successfully developed by using molecular oxygen as the oxidant. The reaction tolerates a variety of functional groups and provides a facile and efficient method for the synthesis of a wide range of (hetero)aryl nitriles.
以分子氧作为氧化剂，成功开发了一种铜介导的（杂）芳烃与氰基乙酸乙酯（一种安全的氰化剂）的直接C-H氰化反应。该反应能耐受多种官能团，为合成多种（杂）芳基腈提供了一种简便有效的方法。
