氰基乙酸乙酯：一种用于钯催化芳基卤化物氰化反应的新型氰化试剂。

Ethyl cyanoacetate: a new cyanating agent for the palladium-catalyzed cyanation of aryl halides.

机构信息

School of Pharmacy, Shanghai University of Traditional Chinese Medicine , Shanghai 201203, P. R. China, and Basilea Pharmaceutica China Ltd. , Haimen, Jiangsu 226100, P. R. China.

出版信息

Org Lett. 2012 Jul 20;14(14):3644-7. doi: 10.1021/ol3014914. Epub 2012 Jul 11.

DOI:10.1021/ol3014914

PMID:22783893

Abstract

A new Pd-catalyzed cyanation reaction has been discovered using ethyl cyanoacetate as the cyanating reagent. A variety of electron-rich and electron-deficient aryl halides were efficiently converted into their corresponding nitriles in good to excellent yields.

摘要

一种新的 Pd 催化氰化反应已经被发现，使用氰基乙酸乙酯作为氰化试剂。各种富电子和缺电子的芳基卤化物可以高效地转化为相应的腈，产率良好到优秀。