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虎杖苷通过激活 Sirt3 和抑制上皮间质转化缓解放射性肺损伤。

Polydatin alleviated radiation-induced lung injury through activation of Sirt3 and inhibition of epithelial-mesenchymal transition.

机构信息

Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, China.

出版信息

J Cell Mol Med. 2017 Dec;21(12):3264-3276. doi: 10.1111/jcmm.13230. Epub 2017 Jun 13.

DOI:10.1111/jcmm.13230
PMID:28609013
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5706589/
Abstract

Radiation-induced lung injury (RILI) is one of the most common and fatal complications of thoracic radiotherapy. It is characterized with two main features including early radiation pneumonitis and fibrosis in later phase. This study was to investigate the potential radioprotective effects of polydatin (PD), which was shown to exert anti-inflammation and anti-oxidative capacities in other diseases. In this study, we demonstrated that PD-mitigated acute inflammation and late fibrosis caused by irradiation. PD treatment inhibited TGF-β1-Smad3 signalling pathway and epithelial-mesenchymal transition. Moreover, radiation-induced imbalance of Th1/Th2 was also alleviated by PD treatment. Besides its free radical scavenging capacity, PD induced a huge increase of Sirt3 in culture cells and lung tissues. The level of Nrf2 and PGC1α in lung tissues was also elevated. In conclusion, our data showed that PD attenuated radiation-induced lung injury through inhibiting epithelial-mesenchymal transition and increased the expression of Sirt3, suggesting PD as a novel potential radioprotector for RILI.

摘要

放射性肺损伤（RILI）是胸部放射治疗中最常见和最致命的并发症之一。其特征是两个主要特征，包括早期放射性肺炎和后期纤维化。本研究旨在探讨虎杖苷（PD）的潜在放射防护作用，PD 在其他疾病中表现出抗炎和抗氧化作用。在这项研究中，我们证明了 PD 减轻了照射引起的急性炎症和晚期纤维化。PD 治疗抑制了 TGF-β1-Smad3 信号通路和上皮间质转化。此外，PD 治疗还减轻了辐射引起的 Th1/Th2 失衡。除了其清除自由基的能力外，PD 在培养细胞和肺组织中诱导 Sirt3 大量增加。肺组织中 Nrf2 和 PGC1α 的水平也升高。总之，我们的数据表明，PD 通过抑制上皮间质转化和增加 Sirt3 的表达来减轻放射性肺损伤，提示 PD 可能是一种治疗 RILI 的新型潜在放射保护剂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05d3/5706589/caeec674cb4a/JCMM-21-3264-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05d3/5706589/da9983880fc9/JCMM-21-3264-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05d3/5706589/013fb101e0b6/JCMM-21-3264-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05d3/5706589/3c2cc9d65f5a/JCMM-21-3264-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05d3/5706589/23f5e929d7f9/JCMM-21-3264-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05d3/5706589/ae630f27b8af/JCMM-21-3264-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05d3/5706589/5c0ccc18c103/JCMM-21-3264-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05d3/5706589/f219b7f61faa/JCMM-21-3264-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05d3/5706589/ae0e3a5f4bb5/JCMM-21-3264-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05d3/5706589/3aa696bca72c/JCMM-21-3264-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05d3/5706589/caeec674cb4a/JCMM-21-3264-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05d3/5706589/da9983880fc9/JCMM-21-3264-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05d3/5706589/013fb101e0b6/JCMM-21-3264-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05d3/5706589/3c2cc9d65f5a/JCMM-21-3264-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05d3/5706589/23f5e929d7f9/JCMM-21-3264-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05d3/5706589/ae630f27b8af/JCMM-21-3264-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05d3/5706589/5c0ccc18c103/JCMM-21-3264-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05d3/5706589/f219b7f61faa/JCMM-21-3264-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05d3/5706589/ae0e3a5f4bb5/JCMM-21-3264-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05d3/5706589/3aa696bca72c/JCMM-21-3264-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05d3/5706589/caeec674cb4a/JCMM-21-3264-g010.jpg

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