Henry M, Kay M M, Viccellio P
Am J Emerg Med. 1985 Jul;3(4):334-6. doi: 10.1016/0735-6757(85)90060-9.
Two cases in which oral ingestion of beta blocker and slow calcium-channel blocker was associated with profound hypotension and bradycardia are reported, including one case in which serum levels of both drugs were documented in the normal range at a time of severe clinical toxicity. Though unresponsive to usual therapeutic interventions, both patients showed an immediate and dramatic response to intravenous calcium chloride. It is recommended that intravenous calcium chloride be considered in any patient using routine doses of these two agents who presents with hypotension and/or bradycardia.
报告了两例口服β受体阻滞剂和慢钙通道阻滞剂导致严重低血压和心动过缓的病例，其中一例在临床毒性严重时两种药物的血清水平记录在正常范围内。尽管对常规治疗干预无反应，但两名患者对静脉注射氯化钙均表现出即时且显著的反应。建议对任何使用常规剂量这两种药物且出现低血压和/或心动过缓的患者考虑静脉注射氯化钙。
