人类免疫缺陷病毒相关子痫前期患者血清中血小板内皮细胞黏附分子-1（PECAM-1）及可溶性血管内皮生长因子受体（sVEGFR）-1和-2的水平
Serum levels of platelet endothelial cell adhesion molecule-1 (PECAM-1) and soluble vascular endothelial growth factor receptor (sVEGFR)-1 and -2 in HIV associated preeclampsia.
作者信息
Thakoordeen Semone, Moodley Jagidesa, Naicker Thajasvarie
机构信息
a Optics and Imaging Centre, University of KwaZulu-Natal , Durban , KwaZulu-Natal , South Africa.
b Women's Health and HIV Research Group, Department of Family Medicine , University of KwaZulu-Natal , Durban , KwaZulu-Natal , South Africa.
出版信息
Hypertens Pregnancy. 2017 May;36(2):168-174. doi: 10.1080/10641955.2017.1280049. Epub 2017 Mar 1.
OBJECTIVE
The angiogenic-antiangiogenic imbalance evident in preeclampsia (PE) may be used as a predictive tool to identify women likely to develop the clinical features in early pregnancy.
METHOD
This retrospective study examined normotensive pregnant (n = 38) and preeclamptic (n = 38) HIV-infected and uninfected women to quantify sVEGFR-1 and -2 and PECAM-1 levels.
RESULTS
In contrast to PECAM-1, sVEGFR-1 and -2 differed according to pregnancy type (p = 0.07; p = 0.001; p = 0.002) but not by HIV status (p = 0.68; p = 0.13; p = 0.43).
CONCLUSION
Irrespective of the HIV status, we report an upregulation of sVEGFR-1 with concomitant decline of PECAM-1 and sVEGFR-2 levels in PE compared to normotensive pregnancies.
目的
子痫前期（PE）中明显的血管生成 - 抗血管生成失衡可作为一种预测工具，用于识别在妊娠早期可能出现临床特征的女性。
方法
这项回顾性研究检查了血压正常的孕妇（n = 38）和子痫前期孕妇（n = 38），这些孕妇均感染或未感染HIV，以量化可溶性血管内皮生长因子受体-1（sVEGFR-1）、可溶性血管内皮生长因子受体-2（sVEGFR-2）和血小板内皮细胞黏附分子-1（PECAM-1）水平。
结果
与PECAM-1不同，sVEGFR-1和sVEGFR-2根据妊娠类型有所不同（p = 0.07；p = 0.001；p = 0.002），但不受HIV感染状态影响（p = 0.68；p = 0.13；p = 0.43）。
结论
无论HIV感染状态如何，我们报告与血压正常的妊娠相比，子痫前期中sVEGFR-1上调，同时PECAM-1和sVEGFR-2水平下降。
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