Roswall Nina, Stangerup Sven-Eric, Cayé-Thomasen Per, Schüz Joachim, Johansen Christoffer, Jensen Steen Solvang, Raaschou-Nielsen Ole, Sørensen Mette
a Danish Cancer Society Research Center , Copenhagen , Denmark.
b Department of Oto-rhino-laryngology, Head and Neck Surgery, and Audiology , Copenhagen University Hospital, Rigshospitalet , Copenhagen , Denmark.
Acta Oncol. 2017 Oct;56(10):1310-1316. doi: 10.1080/0284186X.2017.1337925. Epub 2017 Jun 13.
Few risk factors for sporadic vestibular schwannoma (VS) are known. Several studies have proposed an increased risk with occupational noise exposure, whereas no studies have investigated residential traffic noise exposure as a risk factor. The present study investigated if residential traffic noise was associated with vestibular schwannoma in a large, population-based Danish case-control study.
We identified 1454 VS cases, age above 30 years at diagnosis, between 1990 and 2007. For each case, we selected two random population controls, matched on sex and year of birth. Road and railway traffic noise at the residence was calculated for all present and historical addresses between 1987 and index date. Associations between traffic noise and risk for VS were estimated using conditional logistic regression, adjusted for education, disposable personal income, cohabitation status, railway noise exposure, municipal population density, and municipal income.
A two-year time-weighted mean road traffic noise exposure was associated with an adjusted odds ratio of 0.92 (0.82-1.03) for developing VS, per 10 dB increment. There was no clear trend in categorical analyses. Similarly, linear and categorical analyses of residential railway noise did not suggest an association. We found no interaction with demographics, year of diagnosis, individual and municipal socioeconomic variables, and railway noise exposure. The results did not differ by tumor side, spread or size.
The present study does not suggest an association between residential traffic noise and VS.
散发性前庭神经鞘瘤（VS）的风险因素鲜为人知。多项研究提出职业性噪声暴露会增加患病风险，而尚无研究调查居住环境中的交通噪声暴露是否为风险因素。在一项基于丹麦大规模人群的病例对照研究中，本研究调查了居住环境中的交通噪声与前庭神经鞘瘤之间是否存在关联。
我们确定了1990年至2007年间诊断时年龄在30岁以上的1454例VS病例。对于每例病例，我们随机选择两名与病例性别和出生年份相匹配的人群对照。计算了1987年至索引日期期间所有当前和历史住址处的道路和铁路交通噪声。使用条件逻辑回归估计交通噪声与VS风险之间的关联，并对教育程度、个人可支配收入、同居状况、铁路噪声暴露、市政人口密度和市政收入进行了调整。
每增加10分贝，两年时间加权平均道路交通噪声暴露与VS发病的调整比值比为0.92（0.82 - 1.03）。分类分析中没有明显趋势。同样，居住铁路噪声的线性和分类分析也未显示出关联。我们未发现与人口统计学、诊断年份、个人和市政社会经济变量以及铁路噪声暴露之间存在相互作用。结果在肿瘤侧别、扩散情况或大小方面没有差异。
本研究未表明居住环境中的交通噪声与VS之间存在关联。
