柳氮磺吡啶的哪个成分在类风湿关节炎中具有活性？
Which component of sulphasalazine is active in rheumatoid arthritis?
作者信息
Pullar T, Hunter J A, Capell H A
出版信息
Br Med J (Clin Res Ed). 1985 May 25;290(6481):1535-8. doi: 10.1136/bmj.290.6481.1535.
Abstract
Sulphasalazine is known to be effective as a second line agent in the treatment of rheumatoid arthritis. The two chemical constituents of sulphasalazine (sulphapyridine and 5-aminosalicylic acid) were assessed separately in the treatment of rheumatoid arthritis. Over 24 weeks sulphapyridine showed a pronounced second line effect comparable with sulphasalazine and with a similar toxicity profile, whereas 5-aminosalicylic acid showed only a weak first line effect. Thus sulphapyridine appears to be the active moiety responsible for the second line effect of sulphasalazine in rheumatoid arthritis. The efficacy of the antibacterial component of sulphasalazine yet again permits speculation about the role of a bacterial pathogen in the aetiopathogenesis of rheumatoid disease.
摘要
已知柳氮磺胺吡啶作为二线药物治疗类风湿性关节炎有效。分别评估了柳氮磺胺吡啶的两种化学成分（磺胺吡啶和5-氨基水杨酸）治疗类风湿性关节炎的效果。在24周的时间里，磺胺吡啶显示出与柳氮磺胺吡啶相当的显著二线效应，且毒性特征相似，而5-氨基水杨酸仅显示出微弱的一线效应。因此，磺胺吡啶似乎是柳氮磺胺吡啶在类风湿性关节炎中产生二线效应的活性部分。柳氮磺胺吡啶抗菌成分的疗效再次引发了关于细菌病原体在类风湿性疾病病因发病机制中作用的猜测。
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