糖尿病大鼠视网膜中多巴胺刺激的腺苷酸环化酶和酪氨酸羟化酶
Dopamine-stimulated adenylate cyclase and tyrosine hydroxylase in diabetic rat retina.
作者信息
Northington F K, Hamill R W, Banerjee S P
出版信息
Brain Res. 1985 Jun 24;337(1):151-4. doi: 10.1016/0006-8993(85)91621-x.
The effects of streptozotocin-induced diabetes on the retinal dopaminergic system have been examined in Long-Evans (pigmented) rats. Tyrosine hydroxylase activity was significantly decreased while dopamine-stimulated adenylate cyclase was increased in 2-month-diabetic rats. The observed increase in dopamine-stimulated adenylate cyclase activity in diabetic retinae may be related to neurotransmitter receptor changes because postreceptor activation of adenylate cyclase by guanylyl imidodiphosphate was not altered.
在Long-Evans（有色）大鼠中研究了链脲佐菌素诱导的糖尿病对视网膜多巴胺能系统的影响。在2个月龄的糖尿病大鼠中，酪氨酸羟化酶活性显著降低，而多巴胺刺激的腺苷酸环化酶活性增加。糖尿病视网膜中观察到的多巴胺刺激的腺苷酸环化酶活性增加可能与神经递质受体变化有关，因为鸟苷酰亚胺二磷酸对腺苷酸环化酶的受体后激活没有改变。
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