癌症中的异常糖基化：控制转移的新分子机制。
Aberrant Glycosylation in Cancer: A Novel Molecular Mechanism Controlling Metastasis.
机构信息
Institute for Research and Innovation in Health (i3S), University of Porto, 4200-135 Porto, Portugal; Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), 4200-135 Porto, Portugal.
Institute for Research and Innovation in Health (i3S), University of Porto, 4200-135 Porto, Portugal; Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), 4200-135 Porto, Portugal; Instituto de Ciências Biomédicas Abel Salazar (ICBAS), University of Porto, 4050-313 Porto, Portugal.
出版信息
Cancer Cell. 2017 Jun 12;31(6):733-735. doi: 10.1016/j.ccell.2017.05.012.
Glycosylation alterations are involved in several steps of human cancer pathogenesis. In this issue of Cancer Cell, Agrawal et al. identified the glycosyltransferase FUT8 as a previously unrecognized mediator of melanoma metastasis, establishing core fucosylation as a potential therapeutic target for prevention and treatment of metastatic tumors.
糖基化改变参与了人类癌症发病机制的几个步骤。在本期《癌细胞》杂志中，Agrawal 等人鉴定了糖基转移酶 FUT8 是黑色素瘤转移的一个以前未被识别的介质，确定核心岩藻糖基化为预防和治疗转移性肿瘤的一个潜在治疗靶点。
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