Shi Yujie, Bashian Eleanor E, Hou Yingqin, Wu Peng
Department of Molecular and Cellular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Department of Molecular and Cellular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Cell Chem Biol. 2024 Mar 13. doi: 10.1016/j.chembiol.2024.02.006.
Immunology was one of the first biological fields to embrace chemical approaches. The development of new chemical approaches and techniques has provided immunologists with an impressive arsenal of tools to address challenges once considered insurmountable. This review focuses on advances at the interface of chemistry and immunobiology over the past two decades that have not only opened new avenues in basic immunological research, but also revolutionized drug development for the treatment of cancer and autoimmune diseases. These include chemical approaches to understand and manipulate antigen presentation and the T cell priming process, to facilitate immune cell trafficking and regulate immune cell functions, and therapeutic applications of chemical approaches to disease control and treatment.
免疫学是最早采用化学方法的生物学领域之一。新化学方法和技术的发展为免疫学家提供了一系列令人瞩目的工具，以应对曾经被认为无法克服的挑战。本综述聚焦于过去二十年化学与免疫生物学交叉领域的进展，这些进展不仅在基础免疫学研究中开辟了新途径，还彻底改变了癌症和自身免疫性疾病治疗的药物研发。这些进展包括用于理解和操纵抗原呈递及T细胞启动过程、促进免疫细胞运输和调节免疫细胞功能的化学方法，以及化学方法在疾病控制和治疗中的应用。
