DeMoor J M, Bell D A, Singhal S K
Cell Immunol. 1985 Jul;93(2):406-16. doi: 10.1016/0008-8749(85)90145-5.
The spontaneous in vitro anti-DNA antibody response generated by preautoimmune and many normal mouse spleen cells was suppressed by the addition of syngeneic thymocytes or splenic T cells. Suppressive activity was found in normal mice (DBA/2J) and to an equivalent degree in the autoimmune (New Zealand Black X New Zealand White)F1 (B/W) strain. The suppressor cells were cortisone-resistant, radiosensitive and carried Lyt 1 and Lyt 2 markers. Nonspecific suppression was not involved since the primary and primed in vitro anti-sheep erythrocyte (anti-SRBC) responses were unaffected. Both spontaneous and lipopolysaccharide-stimulated anti-DNA antibody responses could be suppressed. There was no difference in the suppressive activity of cells from young or old, normal or autoimmune mice. These T cells may therefore play a role in preventing the anti-DNA antibody response in normal and young B/W mice, but evidently fail to influence the development of in vivo anti-DNA autoimmune responses in the old B/W mice.
预先自身免疫的和许多正常小鼠脾细胞产生的自发性体外抗DNA抗体反应，会因加入同基因胸腺细胞或脾T细胞而受到抑制。在正常小鼠（DBA/2J）中发现了抑制活性，在自身免疫的（新西兰黑×新西兰白）F1（B/W）品系中也发现了同等程度的抑制活性。抑制细胞对可的松有抗性、对辐射敏感，并带有Lyt 1和Lyt 2标记。由于初次和致敏的体外抗绵羊红细胞（抗SRBC）反应未受影响，所以不涉及非特异性抑制。自发性和脂多糖刺激的抗DNA抗体反应均可被抑制。来自年轻或年老、正常或自身免疫小鼠的细胞在抑制活性上没有差异。因此，这些T细胞可能在正常和年轻的B/W小鼠中对防止抗DNA抗体反应起作用，但显然未能影响年老B/W小鼠体内抗DNA自身免疫反应的发展。
