NZB小鼠的胸腺功能。III. 参与调节抗绵羊红细胞抗体产生的特异性抑制细胞活性受损。
Thymic function in NZB mice. III. Impairment of the activity of specific suppressor cells involved in the regulation of antibody production against sheep red blood cells.
作者信息
Blanchard D, Bach M A
出版信息
Clin Exp Immunol. 1980 Oct;42(1):1-9.
Spleen cells from DBA/2 mice immunized with high numbers of sheep red blood cells specifically suppress the primary anti-SRBC antibody response of syngeneic recipients specifically suppress the primary anti-SRBC antibody response of syngeneic recipients after in vivo transfer. Such suppressive activity of the immune spleen cells is mediated by null cells, or by T cells resistant to the cytotoxic activity of anti-Thy 1.2 antiserum plus complement. The primary anti-SRBC antibody response is much higher in NZB mice than in DBA/2 mice, and the suppressive activity of syngeneic immune spleen cells is much lower in NZB than in DBA/2 recipients. Immune spleen cells from DBA/2 donors do not provide more effective suppression than NZB spleen cells in NZB recipients. Conversely, immune spleen cells from NZB donors strongly suppress the anti-SRBC primary response of DBA/2 recipients to the same extent as DBA/2 immune spleen cells. Finally, NZB mice generate specific suppressor cells but their primary antibody response is not sensitive to this suppressor activity.
用大量绵羊红细胞免疫的DBA/2小鼠的脾细胞，在体内转移后能特异性抑制同基因受体的原发性抗SRBC抗体反应。免疫脾细胞的这种抑制活性由裸细胞或对抗Thy 1.2抗血清加补体的细胞毒性活性有抗性的T细胞介导。NZB小鼠的原发性抗SRBC抗体反应比DBA/2小鼠高得多，同基因免疫脾细胞在NZB受体中的抑制活性比在DBA/2受体中低得多。来自DBA/2供体的免疫脾细胞在NZB受体中并不比NZB脾细胞提供更有效的抑制作用。相反，来自NZB供体的免疫脾细胞能像DBA/2免疫脾细胞一样强烈地抑制DBA/2受体的抗SRBC原发性反应。最后，NZB小鼠产生特异性抑制细胞，但其原发性抗体反应对这种抑制活性不敏感。
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