镍离子对大鼠腮腺微粒体部分中钙离子刺激的三磷酸腺苷酶的体外作用。
Effect of Ni2+ on Ca2+-stimulated adenosine triphosphatase in the microsomal fraction of the rat parotid gland in vitro.
作者信息
Ikeda H
出版信息
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1985;81(1):7-9. doi: 10.1016/0742-8413(85)90083-0.
PMID:2861060
Abstract
Ni2+ inhibited Ca2+-stimulated adenosine triphosphatase activity in the microsomal fraction of the rat parotid gland in vitro. The Ni2+ concentration required for 50% inhibition was 0.45 mM. Inhibition mechanisms of Ni2+ for Ca2+ and ATP were of the competitive type and the noncompetitive type, respectively. The Ki values of Ni2+ for Ca2+ and ATP were 0.52 and 0.59 mM, respectively. The inhibitory effect of Ni2+ was reversible.
摘要
在体外，镍离子（Ni2+）抑制大鼠腮腺微粒体部分中钙离子（Ca2+）刺激的三磷酸腺苷酶活性。50%抑制所需的镍离子浓度为0.45毫摩尔。镍离子对钙离子和三磷酸腺苷（ATP）的抑制机制分别为竞争性类型和非竞争性类型。镍离子对钙离子和三磷酸腺苷的抑制常数（Ki）值分别为0.52和0.59毫摩尔。镍离子的抑制作用是可逆的。
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