Ikeda H
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1985;81(1):7-9. doi: 10.1016/0742-8413(85)90083-0.
Ni2+ inhibited Ca2+-stimulated adenosine triphosphatase activity in the microsomal fraction of the rat parotid gland in vitro. The Ni2+ concentration required for 50% inhibition was 0.45 mM. Inhibition mechanisms of Ni2+ for Ca2+ and ATP were of the competitive type and the noncompetitive type, respectively. The Ki values of Ni2+ for Ca2+ and ATP were 0.52 and 0.59 mM, respectively. The inhibitory effect of Ni2+ was reversible.
在体外，镍离子（Ni2+）抑制大鼠腮腺微粒体部分中钙离子（Ca2+）刺激的三磷酸腺苷酶活性。50%抑制所需的镍离子浓度为0.45毫摩尔。镍离子对钙离子和三磷酸腺苷（ATP）的抑制机制分别为竞争性类型和非竞争性类型。镍离子对钙离子和三磷酸腺苷的抑制常数（Ki）值分别为0.52和0.59毫摩尔。镍离子的抑制作用是可逆的。
