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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Ohzeki H, Terao N, Hayakawa M, Takiguchi H

Int J Biochem. 1983;15(5):603-7. doi: 10.1016/0020-711x(83)90182-9.

The Ca2+-ATPase activity in microsomes of rat submandibular gland was inhibited by pyridoxal 5'-phosphate in vitro. 2. The dissociation constant of the enzyme-pyridoxal 5'-phosphate complex was estimated to be 6.5 mM. 3. The inhibition of pyridoxal 5'-phosphate for both ATP and Ca2+ was competitive. 4. The order of inhibitory effectiveness of pyridoxal 5'-phosphate analogs was pyridoxal 5'-phosphate greater than pyridoxal HCl greater than pyridoxamine 5'-phosphate greater than pyridoxamine HCl. 5. The enzyme-pyridoxal 5'-phosphate complex was nonreducible with sodium borohydride.

体外实验中，磷酸吡哆醛可抑制大鼠下颌下腺微粒体中的Ca2+-ATP酶活性。2. 酶-磷酸吡哆醛复合物的解离常数估计为6.5 mM。3. 磷酸吡哆醛对ATP和Ca2+的抑制作用均为竞争性抑制。4. 磷酸吡哆醛类似物的抑制效力顺序为：磷酸吡哆醛＞盐酸吡哆醛＞磷酸吡哆胺＞盐酸吡哆胺。5. 酶-磷酸吡哆醛复合物不能被硼氢化钠还原。

Ohzeki H, Terao N, Hayakawa M, Takiguchi H

Int J Biochem. 1983;15(5):603-7. doi: 10.1016/0020-711x(83)90182-9.

The Ca2+-ATPase activity in microsomes of rat submandibular gland was inhibited by pyridoxal 5'-phosphate in vitro. 2. The dissociation constant of the enzyme-pyridoxal 5'-phosphate complex was estimated to be 6.5 mM. 3. The inhibition of pyridoxal 5'-phosphate for both ATP and Ca2+ was competitive. 4. The order of inhibitory effectiveness of pyridoxal 5'-phosphate analogs was pyridoxal 5'-phosphate greater than pyridoxal HCl greater than pyridoxamine 5'-phosphate greater than pyridoxamine HCl. 5. The enzyme-pyridoxal 5'-phosphate complex was nonreducible with sodium borohydride.

体外实验中，磷酸吡哆醛可抑制大鼠下颌下腺微粒体中的Ca2+-ATP酶活性。2. 酶-磷酸吡哆醛复合物的解离常数估计为6.5 mM。3. 磷酸吡哆醛对ATP和Ca2+的抑制作用均为竞争性抑制。4. 磷酸吡哆醛类似物的抑制效力顺序为：磷酸吡哆醛＞盐酸吡哆醛＞磷酸吡哆胺＞盐酸吡哆胺。5. 酶-磷酸吡哆醛复合物不能被硼氢化钠还原。