Engbaek F
Eur J Cancer Clin Oncol. 1985 Apr;21(4):469-73. doi: 10.1016/0277-5379(85)90039-2.
An increased synthesis of serotonin by medullary thyroid carcinoma (MTC) has been postulated because an increased concentration of serotonin in the MTC cells and an increased urinary excretion of 5-hydroxyindoleacetic acid have been observed in some patients with MTC. Ten patients with sporadic MTC and 18 patients with familial MTC of either the MEN-IIa or MEN-IIb types were investigated. Three of the patients with MEN-IIa and the patient with MEN-IIb had concomitant pheochromocytomas. The concentrations of serotonin in serum were measured in order to investigate the contributions of the MTC and pheochromocytoma to the overall synthesis of serotonin. The concentrations of serotonin in sera from patients with MTC or MEN-IIa without pheochromocytomas were not different from the concentrations measured in healthy subjects (P greater than 0.10). The four patients with MEN-II syndromes with pheochromocytomas had increased concentrations of serotonin in sera (P less than 0.01), and decreases in the concentrations occurred following adrenalectomy in all four patients. The results show that the MTC made only little if any contribution to the overall synthesis of serotonin in the 28 patients studied; and serotonin was produced in pheochromocytoma tissue from four patients with MEN-II syndromes with pheochromocytoma.
甲状腺髓样癌（MTC）血清素合成增加的假说，源于在一些MTC患者中观察到MTC细胞中血清素浓度升高以及5-羟吲哚乙酸尿排泄增加。研究了10例散发性MTC患者和18例MEN-IIa或MEN-IIb型家族性MTC患者。3例MEN-IIa患者和1例MEN-IIb患者合并嗜铬细胞瘤。检测血清中血清素浓度，以研究MTC和嗜铬细胞瘤对血清素整体合成的贡献。无嗜铬细胞瘤的MTC或MEN-IIa患者血清中血清素浓度与健康受试者测得的浓度无差异（P>0.10）。4例患有嗜铬细胞瘤的MEN-II综合征患者血清中血清素浓度升高（P<0.01），且所有4例患者肾上腺切除术后浓度均下降。结果表明，在所研究的28例患者中，MTC对血清素整体合成的贡献极小（如果有贡献的话）；血清素由4例患有嗜铬细胞瘤的MEN-II综合征患者的嗜铬细胞瘤组织产生。
