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有证据表明,在豚鼠精囊的腹下神经中,ATP作为一种共递质发挥作用。

Evidence that ATP is involved as a co-transmitter in the hypogastric nerve supplying the seminal vesicle of the guinea-pig.

作者信息

Meldrum L A, Burnstock G

出版信息

Eur J Pharmacol. 1985 Apr 16;110(3):363-6. doi: 10.1016/0014-2999(85)90565-5.

DOI:10.1016/0014-2999(85)90565-5
PMID:2861103
Abstract

Electrical field stimulation of the guinea-pig seminal vesicle (4 Hz and 16 Hz) produced a biphasic response. The initial rapid twitch response was blocked by desensitisation of the P2-purinoceptor with alpha, beta-methylene ATP. The slower tonic response was blocked by the alpha-adrenoceptor antagonist phentolamine (10 microM). The present results are similar to those found earlier for the guinea-pig vas deferens, indicating that ATP and NA may be released as co-transmitters from hypogastric nerve fibres.

摘要

对豚鼠精囊进行电场刺激(4赫兹和16赫兹)会产生双相反应。最初的快速抽搐反应可被α,β-亚甲基ATP使P2嘌呤受体脱敏而阻断。较慢的强直性反应可被α-肾上腺素能受体拮抗剂酚妥拉明(10微摩尔)阻断。目前的结果与早期在豚鼠输精管中发现的结果相似,表明ATP和去甲肾上腺素可能作为共同递质从腹下神经纤维释放。

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Evidence that ATP is involved as a co-transmitter in the hypogastric nerve supplying the seminal vesicle of the guinea-pig.有证据表明,在豚鼠精囊的腹下神经中,ATP作为一种共递质发挥作用。
Eur J Pharmacol. 1985 Apr 16;110(3):363-6. doi: 10.1016/0014-2999(85)90565-5.
2
The possibility that adenosine triphosphate is an excitatory transmitter in guinea-pig seminal vesicle.三磷酸腺苷作为豚鼠精囊兴奋性递质的可能性。
Jpn J Pharmacol. 1972 Apr;22(2):269-70. doi: 10.1254/jjp.22.269.
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The possible role of adenosine triphosphate in chemical transmission between the hypogastric nerve terminal and seminal vesicle in the guinea-pig.三磷酸腺苷在豚鼠腹下神经末梢与精囊之间化学传递中的可能作用。
Jpn J Pharmacol. 1973 Aug;23(4):479-90. doi: 10.1254/jjp.23.479.
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Pharmacological evidence that adenosine triphosphate and noradrenaline are co-transmitters in the guinea-pig vas deferens.三磷酸腺苷和去甲肾上腺素作为豚鼠输精管中共同递质的药理学证据。
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Combined hypogastric nerve-vas deferens and -seminal vesicle preparation of guinea pig in vivo.豚鼠体内下腹神经-输精管和-精囊联合制备
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Mechanisms of excitatory transmission in circular smooth muscles of the guinea pig seminal vesicle.豚鼠精囊环形平滑肌中兴奋性传递的机制。
J Urol. 2003 Jan;169(1):390-5. doi: 10.1016/S0022-5347(05)64134-1.
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Direct evidence for concomitant release of noradrenaline, adenosine 5'-triphosphate and neuropeptide Y from sympathetic nerve supplying the guinea-pig vas deferens.来自支配豚鼠输精管的交感神经同时释放去甲肾上腺素、5'-三磷酸腺苷和神经肽Y的直接证据。
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Response of the guinea-pig isolated seminal vesicle to stimulation of the hypogastric nerve.豚鼠离体精囊对腹下神经刺激的反应。
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Evidence that ATP does not act as a cotransmitter with noradrenaline in field-stimulated preparations of rat seminal vesicles.在大鼠精囊的场刺激制备物中,三磷酸腺苷(ATP)并非与去甲肾上腺素共同作为神经递质的证据。
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Age-related changes in purinergic and adrenergic components of sympathetic neurotransmission in guinea-pig seminal vesicles.豚鼠精囊交感神经传递中嘌呤能和肾上腺素能成分的年龄相关变化。
Br J Pharmacol. 1997 Dec;122(7):1411-6. doi: 10.1038/sj.bjp.0701543.

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Differential effects of alpha-beta-methylene ATP on responses to nerve stimulation in SHR and WKY tail arteries.
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J Physiol. 1989 Apr;411:227-43. doi: 10.1113/jphysiol.1989.sp017570.