Meldrum L A, Burnstock G
Eur J Pharmacol. 1985 Apr 16;110(3):363-6. doi: 10.1016/0014-2999(85)90565-5.
Electrical field stimulation of the guinea-pig seminal vesicle (4 Hz and 16 Hz) produced a biphasic response. The initial rapid twitch response was blocked by desensitisation of the P2-purinoceptor with alpha, beta-methylene ATP. The slower tonic response was blocked by the alpha-adrenoceptor antagonist phentolamine (10 microM). The present results are similar to those found earlier for the guinea-pig vas deferens, indicating that ATP and NA may be released as co-transmitters from hypogastric nerve fibres.
对豚鼠精囊进行电场刺激(4赫兹和16赫兹)会产生双相反应。最初的快速抽搐反应可被α,β-亚甲基ATP使P2嘌呤受体脱敏而阻断。较慢的强直性反应可被α-肾上腺素能受体拮抗剂酚妥拉明(10微摩尔)阻断。目前的结果与早期在豚鼠输精管中发现的结果相似,表明ATP和去甲肾上腺素可能作为共同递质从腹下神经纤维释放。