Plazzi P V, Bordi F, Impicciatore M
Farmaco Sci. 1985 Mar;40(3):218-20. doi: 10.1002/chin.198532165.
Carrying on the study of the effects induced by substitution at position 2- of histamine imidazole ring, this article briefly reports the synthesis of 2-(2-oxo-4-imidazolin-4-yl)ethylamine. The pharmacological properties of this compound and its sulphurated analogue 2-(2-thiono-4-imidazolin-4-yl)ethylamine, showed that the marked structural modification of the critical moieties involved in the binding at the H1- and H2-receptors resulted in a loss of histamine-like activity.
在对组胺咪唑环2位取代所产生的效应进行研究的过程中，本文简要报道了2-(2-氧代-4-咪唑啉-4-基)乙胺的合成。该化合物及其硫化类似物2-(2-硫代-4-咪唑啉-4-基)乙胺的药理特性表明，参与与H1和H2受体结合的关键部分的显著结构修饰导致组胺样活性丧失。
