患有色素性干皮病的家族中的癌症
Cancer in families with xeroderma pigmentosum.
作者信息
Swift M, Chase C
出版信息
J Natl Cancer Inst. 1979 Jun;62(6):1415-21.
PMID:286113
Abstract
In 31 families of xeroderma pigmentosum (XP) patients, significantly more blood relatives than spouse controls had had nonmelanoma skin cancer. These family data support the hypothesis that heterozygosity for XP genes may predispose persons to skin cancer, particularly in association with substantial exposure to sunlight.
摘要
在31个患有色素性干皮病（XP）患者的家族中，患非黑素瘤皮肤癌的血亲明显多于配偶对照。这些家族数据支持了这样一种假说，即XP基因的杂合性可能使个体易患皮肤癌，尤其是在大量暴露于阳光下的情况下。
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