John Reena Rachel, Malathi N, Ravindran C, Anandan Soumya
Department of Oral and Maxillofacial Surgery, Vinayaka Mission's Sankarachariyar Dental College, Salem, Tamil Nadu, India.
Department of Oral and Maxillofacial Pathology, Sri Ramachandra Dental College, Chennai, Tamil Nadu, India.
Indian J Dent Res. 2017 Mar-Apr;28(2):187-192. doi: 10.4103/ijdr.IJDR_697_16.
The objective of this paper is to discuss and put forward the various diversified roles of cyclin D1 in cancer. Neoplasia is defined by abnormal regulation of the cell cycle. Cyclin D1 could be a protein derived from the PRAD1, CCND1, or bcl-1 sequence on body 11q13 that is concerned in each traditional regulation of the cell cycle and pathologic process. Within the G1 (resting) part of the cell cycle, cyclin D1 in conjunction with its cyclin-dependent enzyme (cyclin-dependent kinase) partner is accountable for transition to the S (DNA synthesis) part by phosphorylating the merchandise of the metastatic tumor sequence (protein retinoblastoma) that then releases transcription factors vital within the initiation of DNA replication. Amplification of the sequence or overexpression of the cyclin D1 releases a cell from its traditional controls and causes transformation to a malignant composition. Analysis of those changes provides vital diagnostic information in oral carcinogenesis and is of prognostic value in several cancers. Data of cyclin D1's role in malignancy at the assorted sites provide a basis on which future treatment directed against this molecule will proceed.
本文的目的是讨论并提出细胞周期蛋白D1在癌症中的各种多样化作用。肿瘤形成是由细胞周期的异常调节所定义的。细胞周期蛋白D1可能是一种源自11号染色体q13上PRAD1、CCND1或bcl-1序列的蛋白质，它参与细胞周期的正常调节和病理过程。在细胞周期的G1（静止）期，细胞周期蛋白D1与其细胞周期蛋白依赖性激酶伙伴一起，通过磷酸化视网膜母细胞瘤序列（蛋白质视网膜母细胞瘤）的产物，负责向S（DNA合成）期过渡，该产物随后释放出DNA复制起始过程中至关重要的转录因子。该序列的扩增或细胞周期蛋白D1的过度表达使细胞脱离其正常控制并导致向恶性状态转变。对这些变化的分析为口腔癌发生提供了重要的诊断信息，并且在多种癌症中具有预后价值。细胞周期蛋白D1在不同部位恶性肿瘤中作用的数据为未来针对该分子的治疗提供了基础。
