Calvo M V, Nalda M A, Lanao J M, Dominguez-Gil A, Carrasco S
Int J Clin Pharmacol Ther Toxicol. 1985 May;23(5):233-7.
The pharmacokinetics of picobenzide was studied in 14 adult patients undergoing neuroleptoanalgesic sessions. The dose of picobenzide administered was 10 mg/kg by i.v. injection. The pharmacokinetic parameters obtained revealed a good distribution capacity with an average value of the apparent distribution volume at steady state of 28.29 +/- 4.98 1. The drug was also seen to be eliminated rapidly from the organism with an average value of the serum half-life of 2.05 +/- 0.42 h. The determination of the initial distribution kinetics of picobenzide shows that the use of a conventional kinetic model induces an overestimation of the initial distribution volume in turn caused by an underestimation of the initial serum concentration.
在14名接受神经安定镇痛治疗的成年患者中研究了匹考齐特的药代动力学。匹考齐特的给药剂量为静脉注射10mg/kg。获得的药代动力学参数显示分布能力良好，稳态时表观分布容积的平均值为28.29±4.98L。还观察到该药物从体内迅速消除，血清半衰期的平均值为2.05±0.42小时。匹考齐特初始分布动力学的测定表明，使用传统动力学模型会导致初始分布容积的高估，而这又是由初始血清浓度的低估所引起的。
