Mariño E L, Dominguez-Gil A
Int J Clin Pharmacol Ther Toxicol. 1981 Nov;19(11):506-8.
The effects of probenecid on the pharmacokinetic parameters of cefadroxil administered in a single dose of 500 mg are studied. The serum and urine levels of the antibiotic were determined by a microbiologic plate diffusion method. The antibiotic follows a single-compartment model. The half-life of cefadroxil in serum has an average value of 1.13 h, rising to 1.63 h when the antibiotic is associated with probenecid. The apparent distribution volume remains unmodified with a value close to 23 liters. The lag time is 0.25 h in the absence of probenecid, rising to 1.029 h in the presence of the uricosuric agent.
研究了丙磺舒对单次服用500mg头孢羟氨苄药代动力学参数的影响。采用微生物平板扩散法测定抗生素的血清和尿液水平。该抗生素符合单室模型。头孢羟氨苄在血清中的半衰期平均值为1.13小时，当与丙磺舒联用时升至1.63小时。表观分布容积保持不变，值接近23升。在无丙磺舒时滞后时间为0.25小时，在存在促尿酸排泄剂时升至1.029小时。
