血清促甲状腺激素水平与内脏脂肪组织之间的关联：德国东北部一项基于人群的研究。
Association between Serum Thyroid-Stimulating Hormone Levels and Visceral Adipose Tissue: A Population-Based Study in Northeast Germany.
作者信息
Witte Tilman, Völzke Henry, Lerch Markus M, Hegenscheid Katrin, Friedrich Nele, Ittermann Till, Batsis John A
机构信息
The Dartmouth Institute for Health Policy and Clinical Practice, Geisel School of Medicine at Dartmouth, Lebanon, N.H., USA.
Institute for Community Medicine, Departments of, Greifswald, Germany.
出版信息
Eur Thyroid J. 2017 Feb;6(1):12-19. doi: 10.1159/000450977. Epub 2016 Nov 8.
BACKGROUND
Abdominal obesity is a major driver for adverse medical conditions. While an interaction between adipose tissue and thyroid function is thought to exist, to our knowledge, no study has examined the effect of thyroid-stimulating hormone (TSH) on visceral adipose tissue (VAT) in a population-based context.
OBJECTIVE
We determined an association between serum TSH levels and VAT.
METHODS
A sample of 1,021 female and 956 male adults aged 20-79 years was drawn from registry offices in the cross-sectional, population-based Study of Health in Pomerania Trend (SHIP Trend) in Northeast Germany from 2008 to 2012. Our main exposure was serum TSH levels. Our main outcome was VAT measured using magnetic resonance imaging. The possibly mediating role of leptin on the TSH-VAT association was also assessed.
RESULTS
A total of 1,719 participants (87.9%) had serum TSH levels within the reference range. The mean volume of VAT was 5.33 liters for men and 2.83 liters for women. No association between TSH and VAT (β = 0.06, 95% CI: -0.02, 0.14) was observed, and there were no differences detected between sexes. VAT was strongly associated with leptin with a greater effect in women than in men. Leptin was strongly associated with TSH.
CONCLUSIONS
No association between TSH and VAT was observed. Other biomarkers such as leptin may play a role in the relationship between thyroid function and metabolic risk.
背景
腹部肥胖是引发不良健康状况的主要因素。虽然脂肪组织与甲状腺功能之间被认为存在相互作用，但据我们所知，尚无研究在基于人群的背景下考察促甲状腺激素（TSH）对内脏脂肪组织（VAT）的影响。
目的
我们确定血清TSH水平与VAT之间的关联。
方法
从德国东北部基于人群的横断面波美拉尼亚健康趋势研究（SHIP Trend）的登记处抽取了1021名年龄在20 - 79岁之间的成年女性和956名成年男性作为样本。我们的主要暴露因素是血清TSH水平。我们的主要结局是使用磁共振成像测量的VAT。还评估了瘦素在TSH - VAT关联中的可能中介作用。
结果
共有1719名参与者（87.9%）的血清TSH水平在参考范围内。男性VAT的平均体积为5.33升，女性为2.83升。未观察到TSH与VAT之间存在关联（β = 0.06，95%CI：-0.02，0.14），且未检测到性别差异。VAT与瘦素密切相关，女性的影响大于男性。瘦素与TSH密切相关。
结论
未观察到TSH与VAT之间存在关联。其他生物标志物如瘦素可能在甲状腺功能与代谢风险的关系中起作用。
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