Adamska Agnieszka, Raczkowski Andrzej, Stachurska Zofia, Kondraciuk Marcin, Krętowski Adam Jacek, Adamski Marcin, Kowalska Irina, Kamiński Karol Adam
Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Białystok, 15-089 Białystok, Poland.
Department of Population Medicine and Civilization Diseases Prevention, Medical University of Bialystok, 15-089 Białystok, Poland.
J Clin Med. 2022 Apr 11;11(8):2118. doi: 10.3390/jcm11082118.
Body composition, especially an increased amount of fat mass and decreased lean body mass, is connected with metabolic complications. Thyroid hormones can influence body composition pattern. To date, scarce data defining the relationships between thyroid hormones and parameters of body composition using dual-energy X-ray absorptiometry (DXA), especially in cohort studies, are available. Therefore, the aim of the present study was to investigate the relationships among serum concentrations of (thyroid-stimulating hormone (TSH), thyroid hormones, and distribution of fat tissue assessed using the DXA method in a euthyroid cohort from the Białystok PLUS study. We examined 582 euthyroid subjects who were divided into lean (body mass index (BMI) < 25 kg/m2) and overweight/obese (BMI ≥ 25 kg/m2) (84 lean men, 182 overweight/obese men, 160 lean women, and 156 overweight/obese women). Serum concentrations of TSH, free T3 (fT3), and free T4 (fT4) were assessed, and DXA was performed. We observed lower serum levels of fT4 (p = 0.03) and higher serum levels of fT3 (p = 0.04) in overweight/obese vs. lean men, whereas serum levels of TSH did not differ between these groups (p = 0.38). In lean men, we only observed a relationship between serum levels of TSH and visceral adipose tissue (VAT) (r = −0.24, p = 0.02). In overweight/obese men, we found that serum levels of fT3 were positively connected with total fat mass (r = 0.16, p = 0.02), android fat mass (r = 0.15, p = 0.03), and gynoid fat mass (r = 0.17, p = 0.01), but not with VAT (r = 0.03, p = 0.63). We did not observe differences in serum levels of TSH, fT3, and fT4 between lean and overweight/obese women. Additionally, we did not notice relationships between serum levels of thyroid hormones and fat in different regions estimated by DXA in lean and overweight/obese women (all p > 0.05). We concluded that the serum concentration of TSH is connected with VAT in lean men, whereas, in overweight/obese men, higher fT3 is connected with an increased fat amount. These associations are absent in women.
身体成分，尤其是脂肪量增加和去脂体重减少，与代谢并发症相关。甲状腺激素可影响身体成分模式。迄今为止，使用双能X线吸收法（DXA）来确定甲状腺激素与身体成分参数之间关系的数据稀缺，尤其是在队列研究中。因此，本研究的目的是在比得哥什PLUS研究的甲状腺功能正常队列中，调查血清促甲状腺激素（TSH）、甲状腺激素浓度与使用DXA法评估的脂肪组织分布之间的关系。我们检查了582名甲状腺功能正常的受试者，他们被分为瘦组（体重指数（BMI）<25kg/m²）和超重/肥胖组（BMI≥25kg/m²）（84名瘦男性、182名超重/肥胖男性、160名瘦女性和156名超重/肥胖女性）。评估了TSH、游离T3（fT3）和游离T4（fT4）的血清浓度，并进行了DXA检查。我们观察到，与瘦男性相比，超重/肥胖男性的fT4血清水平较低（p = 0.03），fT3血清水平较高（p = 0.04），而两组之间的TSH血清水平没有差异（p = 0.38）。在瘦男性中，我们仅观察到TSH血清水平与内脏脂肪组织（VAT）之间存在关联（r = -0.24，p = 0.02）。在超重/肥胖男性中，我们发现fT3血清水平与总脂肪量（r = 0.16，p = 0.02）、男性型脂肪量（r = 0.15，p = 0.03）和女性型脂肪量（r = 0.17，p = 0.01）呈正相关，但与VAT无关（r = 0.03，p = 0.63）。我们未观察到瘦女性和超重/肥胖女性之间TSH、fT3和fT4的血清水平存在差异。此外，我们未发现瘦女性和超重/肥胖女性中甲状腺激素血清水平与DXA估计的不同区域脂肪之间存在关联（所有p>0.05）。我们得出结论，瘦男性的TSH血清浓度与VAT有关，而在超重/肥胖男性中，较高的fT3与脂肪量增加有关。女性不存在这些关联。
