Sun Qin, He Yixuan, Yang Liang
Yulin Hospital, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Chinese Academy of Medical Sciences & Peking Union Medical College, Peking Union Medical College Hospital, Beijing, Beijing, China.
PLoS One. 2024 Dec 3;19(12):e0314704. doi: 10.1371/journal.pone.0314704. eCollection 2024.
Thyroid stimulating hormone (TSH) has been proven to be closely associated with metabolic abnormalities, including obesity. The objective of this investigation was to scrutinize the intricate association between TSH concentration and obesity, within the adult population. The study focused on a comprehensive examination of the relationship, delving into specific adiposity parameters such as total percent fat (TPF), android percent fat (APF), and gynoid percent fat (GPF).
This study included 809 participants aged 20 and above with normal TSH values from the National Health and Nutrition Examination Survey (NHANES) 2007-2012. Multivariable linear regression models examined the associations of TSH concentration with TPF, APF, and GPF. Subgroup analyses, stratified by sex, were performed using multivariable linear regression. Fitted smoothing curves and generalized additive models addressed non-linear relationships between TSH and TPF, APF, and GPF.
In fully adjusted models, a significant positive association was observed between TPF and TSH (β = 0.01, 95% CI: 0.00-0.02, p<0.05), while no such association was evident in APF and GPF. Upon sex stratification, females exhibited significant positive correlations between TSH and TPF, APF, and GPF (all p < 0.001), contrasting with males where no such correlations were found. Notably, a non-linear association was identified in males, specifically a U-shaped curve (inflection point: 32.6%) for TSH and APF.
The study unveiled a statistically significant positive association between TSH and TPF in adults. Upon sex stratification, similar statistically significant relationships were observed between TSH and adiposity (TPF, APF, GPF) in females, while males exhibited a U-shaped non-linear relationship between TSH and APF.
促甲状腺激素（TSH）已被证明与包括肥胖在内的代谢异常密切相关。本研究的目的是在成年人群中仔细研究TSH浓度与肥胖之间的复杂关联。该研究聚焦于对这种关系进行全面检查，深入探究特定的肥胖参数，如总脂肪百分比（TPF）、男性型脂肪百分比（APF）和女性型脂肪百分比（GPF）。
本研究纳入了2007 - 2012年美国国家健康与营养检查调查（NHANES）中809名20岁及以上且TSH值正常的参与者。多变量线性回归模型检验了TSH浓度与TPF、APF和GPF之间的关联。使用多变量线性回归按性别进行亚组分析。拟合平滑曲线和广义相加模型处理TSH与TPF、APF和GPF之间的非线性关系。
在完全调整模型中，观察到TPF与TSH之间存在显著正相关（β = 0.01，95%置信区间：0.00 - 0.02，p<0.05），而在APF和GPF中未观察到此类关联。按性别分层后，女性的TSH与TPF、APF和GPF之间呈现显著正相关（均p < 0.001），而男性未发现此类相关性。值得注意的是，在男性中发现了一种非线性关联，特别是TSH与APF之间呈U形曲线（拐点：32.6%）。
该研究揭示了成年人中TSH与TPF之间存在统计学显著的正相关。按性别分层后，女性中TSH与肥胖（TPF、APF、GPF）之间观察到类似的统计学显著关系，而男性中TSH与APF之间呈现U形非线性关系。
