Department of Medical Oncology, Centro Integral Oncológico Clara Campal, Hospital Universitario Madrid Norte Sanchinarro, Madrid, Spain.
Department of Medical Oncology, Hospital Regional Universitario de Málaga, Málaga, Spain.
Clin Transl Oncol. 2017 Oct;19(10):1193-1198. doi: 10.1007/s12094-017-1680-8. Epub 2017 Jun 13.
Nowadays and given the improvement in response rate with the new schemes of treatment with chemotherapy, the interest in neoadjuvant treatment for pancreatic ductal adenocarcinoma, allowing the early application of systemic therapies, has also increased. However, treatment selection fundamentally depends on decisions taken by multidisciplinary committees due to the absence of randomized trials on this indication and because the available evidence is based primarily on small studies. The present manuscript tries to establish recommendations based on the available evidence and expert opinion to correctly select the indication, the type of treatment, as well as its duration and how to correctly follow-up patients during treatment with chemotherapy.
如今，随着新的化疗治疗方案反应率的提高，人们对新辅助治疗胰腺导管腺癌的兴趣也有所增加，这使得早期应用系统治疗成为可能。然而，由于针对该适应证尚无随机试验，并且现有证据主要基于小型研究，因此治疗选择从根本上取决于多学科委员会做出的决策。本文试图根据现有证据和专家意见制定推荐意见，以正确选择适应证、治疗类型，以及治疗的持续时间，并在化疗期间正确随访患者。
