Bloom F E
J Immunol. 1985 Aug;135(2 Suppl):743s-745s.
Some general principles of peptide and other transmitter actions in the CNS may be applicable to determining how central, autonomic, or blood-borne transmitter signals may regulate the responsiveness of the cells of the immune system. For the resolution of how and where transmitters act in the CNS, research in cellular neurobiology has made substantial recent progress in three specific areas of work: neuronal connectivity, synaptic mechanisms, and neuronal transmitters, Together, the new circuits, new transmitters, and new receptor mechanisms provide a rich repertoire of signaling mechanisms that transcend earlier notions of "classical" excitatory or inhibitory transmission modes and that are pertinent to regulation of immune response mechanisms.
中枢神经系统中肽及其他递质作用的一些一般原则，可能适用于确定中枢、自主或血源性递质信号如何调节免疫系统细胞的反应性。为了解递质在中枢神经系统中如何以及在何处起作用，细胞神经生物学研究在三个特定工作领域取得了重大进展：神经元连接、突触机制和神经元递质。新的回路、新的递质和新的受体机制共同提供了丰富的信号传导机制，超越了早期 “经典” 兴奋性或抑制性传递模式的概念，并且与免疫反应机制的调节相关。
