Paulson Daniel, Shah Mona, Herring Danielle, Scott Rosanna, Herrera Manuel, Brush David, Bassett Rachel
Department of Psychology, University of Central Florida, Orlando, FL, USA.
Int J Geriatr Psychiatry. 2018 Feb;33(2):316-324. doi: 10.1002/gps.4746. Epub 2017 Jun 14.
Moderate alcohol use has been broadly associated with health benefits among older adults, including improved mood. Aims of this study were to evaluate the relationship of moderate alcohol use and depressive symptomatology over a period of eight years, and to examine inflammation, indicated by C-reactive protein (CRP), as one mechanism by which this relationship functions.
The study included 3177 community-dwelling participants over the age of 65 in 2008 drawn from the Health and Retirement Study. Data from the 2006, 2008, 2012, and 2014 waves were used. Alcohol use was measured via self-report and was dichotomized as abstinent (0 drinks per week) and moderate (1-14 drinks per week). Inflammation was measured using CRP, which was collected using an enzyme-linked immunosorbent assay and provided in units of μg/mL. Control variables included gender, age, body mass index (BMI), and medical burden.
A latent growth curve model with full information maximum likelihood was used, with results revealing that moderate drinkers endorsed fewer depressive symptoms at baseline and a steeper rate of change over time. Abstinent respondents' depressive symptomatology was characterized by a more linear change rate. Further, moderate drinkers had lower CRP levels suggesting that inflammation partially mediates the relationship between moderate alcohol use and depressive symptomatology.
Moderate alcohol use predicts fewer depressive symptoms among older adults. This relationship is partially moderated by CRP and is eroded by the passage of time. Future research should identify additional mechanisms relating alcohol to positive health outcomes and less depressive symptomatology. Copyright © 2017 John Wiley & Sons, Ltd.
适度饮酒与老年人的健康益处广泛相关，包括改善情绪。本研究的目的是评估八年间适度饮酒与抑郁症状之间的关系，并检验以C反应蛋白（CRP）表示的炎症作为这种关系发挥作用的一种机制。
该研究纳入了2008年从健康与退休研究中抽取的3177名65岁以上的社区居住参与者。使用了2006年、2008年、2012年和2014年的数据。饮酒情况通过自我报告进行测量，并分为戒酒者（每周饮酒0杯）和适度饮酒者（每周饮酒1 - 14杯）。炎症通过CRP进行测量，CRP采用酶联免疫吸附测定法收集，以μg/mL为单位提供。控制变量包括性别、年龄、体重指数（BMI）和医疗负担。
使用了具有全信息最大似然法的潜在增长曲线模型，结果显示适度饮酒者在基线时认可的抑郁症状较少，且随时间变化的速率更快。戒酒者的抑郁症状表现为变化率更呈线性。此外，适度饮酒者的CRP水平较低，表明炎症部分介导了适度饮酒与抑郁症状之间的关系。
适度饮酒可预测老年人出现较少的抑郁症状。这种关系部分由CRP调节，且会随着时间的推移而减弱。未来的研究应确定酒精与积极健康结果及较少抑郁症状相关的其他机制。版权所有© 2017约翰威立父子有限公司。
