Crossley V J, Debnath A, Chang Y M, Fowkes R C, Elliott J, Syme H M
Department of Clinical Science and Services, Royal Veterinary College, University of London, London, UK.
Research Support Office, Royal Veterinary College, University of London, London, UK.
J Vet Intern Med. 2017 Jul;31(4):1028-1034. doi: 10.1111/jvim.14737. Epub 2017 Jun 13.
Hyperthyroidism is very common in older cats, but the etiopathogenesis is poorly understood. Decreased risk of hyperthyroidism has been reported in certain colorpoint breeds, and this observation previously has been hypothesized to result from relatively greater tyrosine availability for thyroid hormone production because of limited ability to convert tyrosine to melanin pigment. However, studies investigating a potential link between coat pigmentation and risk of hyperthyroidism are limited.
To identify associations between coat phenotype and hyperthyroidism by investigation of breed, coat color, and hair length as risk factors for the disease.
Data were used from 4,705 cats aged ≥10 years, referred to a single veterinary teaching hospital (2006-2014) in the United Kingdom.
Retrospective, epidemiological, cross-sectional study using Bayesian multivariable logistic regression to assess risk factors for hyperthyroidism.
Burmese (odds ratio [OR], 0.01; 0.00-0.23; P = .004), Tonkinese (OR, 0.05; 0.00-0.95; P = .046), Persian (OR, 0.21; 0.10-0.44; P < .001), Siamese (OR, 0.27; 0.12-0.61; P = .002), Abyssinian (OR, 0.04; 0.00-0.74; P = .031), and British shorthair (OR, 0.47; 0.28-0.79; P = .004) breeds had decreased risk of hyperthyroidism compared to domestic shorthairs. Longhaired, nonpurebred cats (OR, 1.30; 1.03-1.64; P = .028) were at increased risk of hyperthyroidism. Coat color/pattern was not associated with hyperthyroidism in nonpurebred cats.
We identified decreased risk of hyperthyroidism in the Tonkinese, Abyssinian, and British shorthair breeds, identified an association between risk of hyperthyroidism and hair length, and confirmed decreased risk in Burmese, Siamese, and Persian breeds. Additional studies are warranted to further investigate these findings.
甲状腺功能亢进在老年猫中非常常见，但其发病机制尚不清楚。据报道，某些重点色品种的猫患甲状腺功能亢进的风险较低，此前有研究推测，这是由于这些猫将酪氨酸转化为黑色素的能力有限，因而有相对更多的酪氨酸可用于甲状腺激素的合成。然而，关于被毛色素沉着与甲状腺功能亢进风险之间潜在联系的研究有限。
通过调查品种、毛色和毛长等疾病风险因素，确定被毛表型与甲状腺功能亢进之间的关联。
使用了来自英国一家兽医教学医院（2006 - 2014年）的4705只年龄≥10岁的猫的数据。
采用回顾性、流行病学横断面研究，使用贝叶斯多变量逻辑回归评估甲状腺功能亢进的风险因素。
与家猫相比，缅甸猫（优势比[OR]，0.01；0.00 - 0.23；P = 0.004）、东奇尼猫（OR，0.05；0.00 - 0.95；P = 0.046）、波斯猫（OR，0.21；0.10 - 0.44；P < 0.001）、暹罗猫（OR，0.27；0.12 - 0.61；P = 0.002）、阿比西尼亚猫（OR，0.04；0.00 - 0.74；P = 0.031）和英国短毛猫（OR，0.47；0.28 - 0.79；P = 0.004）患甲状腺功能亢进的风险较低。长毛非纯种猫（OR，1.30；1.03 - 1.64；P = 0.028）患甲状腺功能亢进的风险增加。在非纯种猫中，毛色/花纹与甲状腺功能亢进无关。
我们发现东奇尼猫、阿比西尼亚猫和英国短毛猫患甲状腺功能亢进的风险降低，确定了甲状腺功能亢进风险与毛长之间的关联，并证实缅甸猫、暹罗猫和波斯猫的风险降低。需要进一步研究以深入探讨这些发现。
