Qin Ken, He Min, Cao Xiao-Tao, Yang Han-Wei, Yang Ying, Wang You-Juan, Yu Chuan, An Zhen-Mei, Li She-Yu
Physical Examination Center, West China Hospital, Sichuan University, Chengdu 610041, China.
Chinese Evidence-based Medicine Center, West China Hospital, Sichuan University, Chengdu 610041, China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2017 Jan;48(1):17-22.
To investigate the association between obesity and osteoporosis in men aged above 50 in Chengdu.
Male participants aged above 50 were recruited from those who visited West China Hospital of Sichuan University for health examinations. Bone mineral density was measured by MetriScan Bone Densitometry. The participants were divided into three groups according to T values: normal, osteopenia and osteoporosis.
About 5.75% (525 cases) of the 9 135 male participants had osteoporosis. The three groups had significant different anthropometric parameters, including body mass, waist circumference, hip circumference, body mass index (BMI), waist-hip ratio (WHR), waist-height ratio (WHtR), a body shape index (ABSI), and body roundness index (BRI)( <0.01). The participants with the highest quartile (Q4) of BMI, BRI, WHtR, WHR, ABSI, waist circumference and height had an age-adjusted odds ratios () of 0.443 [95% confidence interval ( ): 0.342-0.574), 0.580 (95% : 0.454-0.740), 0.587 (95% : 0.460-0.751), 0.664 (95% : 0.516-0.854], 1.369 (95% : 1.069-1.751), 0.634 (95% : 0.497-0.809), and 1.357 (95% : 1.047-1.758), respectively, for osteoporosis compared with those with the lowest quartile (Q1). The area under cures () of receiver operator characteristic (ROC) curve of BMI for osteoporosis was 0.606 (95% :0.580-0.632).
Large body mass was negatively associated with osteoporosis in middle and old aged men. BMI is the strongest predictor of osteoporosis. Further longitudinal studies are required to verify such asscoiations.
调查成都地区50岁以上男性肥胖与骨质疏松症之间的关联。
从到四川大学华西医院进行健康体检的人群中招募50岁以上男性参与者。采用MetriScan骨密度仪测量骨密度。根据T值将参与者分为三组：正常、骨量减少和骨质疏松。
9135名男性参与者中约5.75%（525例）患有骨质疏松症。三组在人体测量参数方面存在显著差异，包括体重、腰围、臀围、体重指数（BMI）、腰臀比（WHR）、腰高比（WHtR）、体型指数（ABSI）和身体圆润度指数（BRI）（<0.01）。与四分位数最低组（Q1）相比，BMI、BRI、WHtR、WHR、ABSI、腰围和身高处于最高四分位数（Q4）的参与者患骨质疏松症的年龄调整比值比（OR）分别为0.443[95%置信区间（CI）：0.342 - 0.574]、0.580（95%CI：0.454 - 0.740）、0.587（95%CI：0.460 - 0.751）、0.664（95%CI：0.516 - 0.854）、1.369（95%CI：1.069 - 1.751）、0.634（95%CI：0.497 - 0.809）和1.357（95%CI：1.047 - 1.758）。BMI用于骨质疏松症诊断的受试者工作特征（ROC）曲线下面积（AUC）为0.606（95%CI：0.580 - 0.632）。
中老年男性体重过大与骨质疏松症呈负相关。BMI是骨质疏松症最强的预测指标。需要进一步的纵向研究来验证这种关联。
