可见光介导的咪唑并[1,2-a]吡啶与2-溴唑的C3-唑基化反应

Visible-light-mediated C3-azolylation of imidazo[1,2-a]pyridines with 2-bromoazoles.

作者信息

Chang Qing, Wu Zhongjie, Yu Lu, Liu Ping, Sun Peipei

机构信息

College of Chemistry and Materials Science, Jiangsu Provincial Key Laboratory of Material Cycle Processes and Pollution Control, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Nanjing Normal University, Nanjing 210023, China.

出版信息

Org Biomol Chem. 2017 Jun 27;15(25):5318-5324. doi: 10.1039/c7ob00883j.

DOI:10.1039/c7ob00883j

PMID:28613336

Abstract

The C3-azolylation of imidazo[1,2-a]pyridines was developed via a visible light-mediated reaction of imidazopyridines with 2-bromoazoles catalyzed by Ir(ppy)(dtbbpy)PF under mild conditions. For the imidazo[1,2-a]pyridines with various substituents on benzene or the pyridine ring and a variety of azoles, the reaction proceeded smoothly to give 3-(azol-2-yl)imidazo[1,2-a]pyridines in moderate to good yields.

摘要

咪唑并[1,2 - a]吡啶的C3 - 唑基化反应是通过在温和条件下，由Ir(ppy)(dtbbpy)PF催化的咪唑并吡啶与2 - 溴唑的可见光介导反应实现的。对于苯环或吡啶环上带有各种取代基的咪唑并[1,2 - a]吡啶以及各种唑类，该反应顺利进行，以中等至良好的产率得到3 - (唑 - 2 - 基)咪唑并[1,2 - a]吡啶。