Elston Thomas W, Bilkey David K
Brain Health Research Centre, University of Otago, Dunedin 9016, New Zealand; Department of Psychology, University of Otago, Dunedin 9016, New Zealand.
Brain Health Research Centre, University of Otago, Dunedin 9016, New Zealand; Department of Psychology, University of Otago, Dunedin 9016, New Zealand.
Cell Rep. 2017 Jun 13;19(11):2220-2230. doi: 10.1016/j.celrep.2017.05.062.
Information gained during goal pursuit motivates adaptive behavior. The anterior cingulate cortex (ACC) supports adaptive behavior, but how ACC signals are translated into motivational signals remains unclear. Rats with implants in the ACC and ventral tegmental area (VTA), a dopaminergic brain area implicated in motivation, were trained to run laps around a rectangular track for a fixed reward, where each lap varied in physical effort (a 30-cm climbable barrier). Partial directed coherence analysis of local field potentials revealed that ACC theta (4-12 Hz) activity increased as rats entered the barrier-containing region of the maze in trials when the barrier was absent and predicted similar changes in VTA theta activity. This did not occur in effortful, barrier-present trials. These data suggest that the ACC provides a top-down modulating signal to the VTA that can influence the motivation with which to pursue a reward.
在目标追求过程中获得的信息会激发适应性行为。前扣带回皮质（ACC）支持适应性行为，但ACC信号如何转化为动机信号仍不清楚。在ACC和腹侧被盖区（VTA，一个与动机有关的多巴胺能脑区）植入电极的大鼠，被训练在一个矩形轨道上跑圈以获取固定奖励，每一圈的体力消耗不同（有一个30厘米高的可攀爬障碍）。对局部场电位的部分定向相干分析表明，在没有障碍的试验中，当大鼠进入迷宫中包含障碍的区域时，ACC的θ波（4 - 12赫兹）活动增加，并预测VTA的θ波活动会有类似变化。在有障碍的费力试验中则不会出现这种情况。这些数据表明，ACC向VTA提供自上而下的调节信号，该信号可以影响追求奖励的动机。
