长链非编码RNA（lncRNAs）及其对炎症反应的转录调控。
Long non-coding RNAs (lncRNAs) and their transcriptional control of inflammatory responses.
作者信息
Mathy Nicholas W, Chen Xian-Ming
机构信息
Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, Nebraska 68178.
Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, Nebraska 68178.
出版信息
J Biol Chem. 2017 Jul 28;292(30):12375-12382. doi: 10.1074/jbc.R116.760884. Epub 2017 Jun 14.
Abstract
Long non-coding RNAs (lncRNAs) have emerged as potential key regulators of the inflammatory response, particularly by modulating the transcriptional control of inflammatory genes. lncRNAs may act as an enhancer or suppressor to inflammatory transcription, function as scaffold molecules through interactions with RNA-binding proteins in chromatin remodeling complexes, and modulate dynamic and epigenetic control of inflammatory transcription in a gene-specific and time-dependent fashion. Here, we will review recent literature regarding the role of lncRNAs in transcriptional control of inflammatory responses. Better understanding of lncRNA regulation of inflammation will provide novel targets for the development of new therapeutic strategies.
摘要
长链非编码RNA（lncRNAs）已成为炎症反应潜在的关键调节因子，尤其是通过调节炎症基因的转录控制。lncRNAs可能作为炎症转录的增强子或抑制子，通过与染色质重塑复合物中的RNA结合蛋白相互作用充当支架分子，并以基因特异性和时间依赖性方式调节炎症转录的动态和表观遗传控制。在此，我们将综述关于lncRNAs在炎症反应转录控制中作用的近期文献。更好地理解lncRNA对炎症的调节将为开发新的治疗策略提供新的靶点。
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