A Role for AnkyrinG in Maturation and Maintenance of the Nodes of Ranvier.
作者信息
Yang Benjamin, Curran Bridget M, Tymanskyj Stephen R
机构信息
Department of Neuroscience, Vickie and Jack Farber Institute for Neuroscience, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107.
Department of Neuroscience, Vickie and Jack Farber Institute for Neuroscience, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107
出版信息
J Neurosci. 2017 Jun 14;37(24):5796-5797. doi: 10.1523/JNEUROSCI.0858-17.2017.
Abstract
摘要
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Molecular composition of the node of Ranvier: identification of ankyrin-binding cell adhesion molecules neurofascin (mucin+/third FNIII domain-) and NrCAM at nodal axon segments.郎飞结的分子组成：在节点轴突节段鉴定出与锚蛋白结合的细胞黏附分子神经束蛋白（黏蛋白阳性/第三个纤连蛋白III结构域阴性）和NrCAM。
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Postnatal Loss of Neuronal and Glial Neurofascins Differentially Affects Node of Ranvier Maintenance and Myelinated Axon Function.出生后神经元和胶质神经束蛋白的缺失对郎飞结的维持和有髓轴突功能有不同影响。
Front Cell Neurosci. 2017 Feb 3;11:11. doi: 10.3389/fncel.2017.00011. eCollection 2017.
2
Early and Late Loss of the Cytoskeletal Scaffolding Protein, Ankyrin G Reveals Its Role in Maturation and Maintenance of Nodes of Ranvier in Myelinated Axons.细胞骨架支架蛋白锚蛋白G的早期和晚期缺失揭示了其在有髓轴突郎飞结成熟和维持中的作用。
J Neurosci. 2017 Mar 8;37(10):2524-2538. doi: 10.1523/JNEUROSCI.2661-16.2017. Epub 2017 Feb 1.
3
A hierarchy of ankyrin-spectrin complexes clusters sodium channels at nodes of Ranvier.连接蛋白-锚蛋白复合体层级结构将钠离子通道聚集在郎飞结处。
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Candidate autism gene screen identifies critical role for cell-adhesion molecule CASPR2 in dendritic arborization and spine development.候选自闭症基因筛查确定细胞黏附分子 CASPR2 在树突分支和棘突发育中的关键作用。
Proc Natl Acad Sci U S A. 2012 Oct 30;109(44):18120-5. doi: 10.1073/pnas.1216398109. Epub 2012 Oct 16.
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Assembly and maintenance of nodes of ranvier rely on distinct sources of proteins and targeting mechanisms.郎飞结的形成和维持依赖于不同的蛋白质来源和靶向机制。
Neuron. 2012 Jan 12;73(1):92-107. doi: 10.1016/j.neuron.2011.10.016.
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Absence of CNTNAP2 leads to epilepsy, neuronal migration abnormalities, and core autism-related deficits.CNTNAP2 的缺失导致癫痫、神经元迁移异常和核心自闭症相关缺陷。
Cell. 2011 Sep 30;147(1):235-46. doi: 10.1016/j.cell.2011.08.040.
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A critical role for Neurofascin in regulating action potential initiation through maintenance of the axon initial segment.神经束蛋白在维持轴突起始段中对动作电位起始的调节作用至关重要。
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Nodes of Ranvier and axon initial segments are ankyrin G-dependent domains that assemble by distinct mechanisms.郎飞结和轴突起始段是通过不同机制组装的锚蛋白G依赖结构域。
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