P2X7 receptor antagonism in amyotrophic lateral sclerosis.
作者信息
Sluyter Ronald, Bartlett Rachael, Ly Diane, Yerbury Justin J
机构信息
School of Biological Sciences and Center for Medical and Molecular Bioscience, University of Wollongong, Wollongong, NSW, Australia; Illawarra Health and Medical Research Institute, NSW, Wollongong, Australia.
出版信息
Neural Regen Res. 2017 May;12(5):749-750. doi: 10.4103/1673-5374.206643.
Abstract
摘要
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本文引用的文献
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Current view and perspectives in amyotrophic lateral sclerosis.肌萎缩侧索硬化症的当前观点与展望
Neural Regen Res. 2017 Feb;12(2):181-184. doi: 10.4103/1673-5374.200794.
2
P2X7 antagonism using Brilliant Blue G reduces body weight loss and prolongs survival in female SOD1 amyotrophic lateral sclerosis mice.使用亮蓝G拮抗P2X7可减轻雌性超氧化物歧化酶1型肌萎缩侧索硬化症小鼠的体重减轻并延长其生存期。
PeerJ. 2017 Mar 1;5:e3064. doi: 10.7717/peerj.3064. eCollection 2017.
3
The microglial ATP-gated ion channel P2X7 as a CNS drug target.作为中枢神经系统药物靶点的小胶质细胞ATP门控离子通道P2X7
Glia. 2016 Oct;64(10):1772-87. doi: 10.1002/glia.23001. Epub 2016 May 24.
4
Purinergic contribution to amyotrophic lateral sclerosis.嘌呤能在肌萎缩侧索硬化症中的作用
Neuropharmacology. 2016 May;104:180-93. doi: 10.1016/j.neuropharm.2015.10.026. Epub 2015 Oct 26.
5
Spinal cord pathology is ameliorated by P2X7 antagonism in a SOD1-mutant mouse model of amyotrophic lateral sclerosis.在肌萎缩侧索硬化症的超氧化物歧化酶1突变小鼠模型中，P2X7拮抗剂可改善脊髓病理学变化。
Dis Model Mech. 2014 Sep;7(9):1101-9. doi: 10.1242/dmm.017038. Epub 2014 Jul 18.
6
Ablation of P2X7 receptor exacerbates gliosis and motoneuron death in the SOD1-G93A mouse model of amyotrophic lateral sclerosis.P2X7 受体消融加重肌萎缩侧索硬化症 SOD1-G93A 小鼠模型中的神经胶质增生和运动神经元死亡。
Hum Mol Genet. 2013 Oct 15;22(20):4102-16. doi: 10.1093/hmg/ddt259. Epub 2013 Jun 4.
7
Motor neuron dysfunction in a mouse model of ALS: gender-dependent effect of P2X7 antagonism.肌萎缩侧索硬化症小鼠模型中的运动神经元功能障碍：P2X7 拮抗剂的性别依赖性作用。
Toxicology. 2013 Sep 6;311(1-2):69-77. doi: 10.1016/j.tox.2013.04.004. Epub 2013 Apr 11.
8
P2X7 receptor activation induces reactive oxygen species formation and cell death in murine EOC13 microglia.P2X7 受体激活诱导小鼠 EOC13 小胶质细胞中活性氧的形成和细胞死亡。
Mediators Inflamm. 2013;2013:271813. doi: 10.1155/2013/271813. Epub 2013 Jan 27.
9
Inhibition of neuronal voltage-gated sodium channels by brilliant blue G.亮蓝 G 对神经元电压门控钠离子通道的抑制作用。
Mol Pharmacol. 2011 Aug;80(2):247-57. doi: 10.1124/mol.110.070276. Epub 2011 May 2.
10
Effects of estrogen on lifespan and motor functions in female hSOD1 G93A transgenic mice.雌激素对雌性人超氧化物歧化酶1 G93A转基因小鼠寿命和运动功能的影响。
J Neurol Sci. 2008 May 15;268(1-2):40-7. doi: 10.1016/j.jns.2007.10.024. Epub 2007 Dec 4.
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