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P2X7 receptor antagonism in amyotrophic lateral sclerosis.

作者信息

Sluyter Ronald, Bartlett Rachael, Ly Diane, Yerbury Justin J

机构信息

School of Biological Sciences and Center for Medical and Molecular Bioscience, University of Wollongong, Wollongong, NSW, Australia; Illawarra Health and Medical Research Institute, NSW, Wollongong, Australia.

出版信息

Neural Regen Res. 2017 May;12(5):749-750. doi: 10.4103/1673-5374.206643.

DOI:10.4103/1673-5374.206643
PMID:28616029
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5461610/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2e2/5461610/4e408264c942/NRR-12-749-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2e2/5461610/4e408264c942/NRR-12-749-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2e2/5461610/4e408264c942/NRR-12-749-g001.jpg

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本文引用的文献

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Current view and perspectives in amyotrophic lateral sclerosis.肌萎缩侧索硬化症的当前观点与展望
Neural Regen Res. 2017 Feb;12(2):181-184. doi: 10.4103/1673-5374.200794.
2
P2X7 antagonism using Brilliant Blue G reduces body weight loss and prolongs survival in female SOD1 amyotrophic lateral sclerosis mice.使用亮蓝G拮抗P2X7可减轻雌性超氧化物歧化酶1型肌萎缩侧索硬化症小鼠的体重减轻并延长其生存期。
PeerJ. 2017 Mar 1;5:e3064. doi: 10.7717/peerj.3064. eCollection 2017.
3
The microglial ATP-gated ion channel P2X7 as a CNS drug target.作为中枢神经系统药物靶点的小胶质细胞ATP门控离子通道P2X7
人类P2X7离子通道基因中三种常见编码多态性的起源、分布及功能
Front Pharmacol. 2022 Nov 18;13:1033135. doi: 10.3389/fphar.2022.1033135. eCollection 2022.
4
P2X7 receptor activation mediates superoxide dismutase 1 (SOD1) release from murine NSC-34 motor neurons.P2X7 受体的激活介导了来自鼠 NSC-34 运动神经元的超氧化物歧化酶 1（SOD1）的释放。
Purinergic Signal. 2022 Dec;18(4):451-467. doi: 10.1007/s11302-022-09863-5. Epub 2022 Apr 28.
5
Novel P2X7 Antagonist Ameliorates the Early Phase of ALS Disease and Decreases Inflammation and Autophagy in SOD1-G93A Mouse Model.新型 P2X7 拮抗剂改善 ALS 疾病早期阶段并减少 SOD1-G93A 小鼠模型中的炎症和自噬。
Int J Mol Sci. 2021 Sep 30;22(19):10649. doi: 10.3390/ijms221910649.
6
Implication of Neuronal Versus Microglial P2X4 Receptors in Central Nervous System Disorders.神经元与小胶质细胞P2X4受体在中枢神经系统疾病中的作用
Neurosci Bull. 2020 Nov;36(11):1327-1343. doi: 10.1007/s12264-020-00570-y. Epub 2020 Sep 5.
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4
Purinergic contribution to amyotrophic lateral sclerosis.嘌呤能在肌萎缩侧索硬化症中的作用
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5
Spinal cord pathology is ameliorated by P2X7 antagonism in a SOD1-mutant mouse model of amyotrophic lateral sclerosis.在肌萎缩侧索硬化症的超氧化物歧化酶1突变小鼠模型中，P2X7拮抗剂可改善脊髓病理学变化。
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Ablation of P2X7 receptor exacerbates gliosis and motoneuron death in the SOD1-G93A mouse model of amyotrophic lateral sclerosis.P2X7 受体消融加重肌萎缩侧索硬化症 SOD1-G93A 小鼠模型中的神经胶质增生和运动神经元死亡。
Hum Mol Genet. 2013 Oct 15;22(20):4102-16. doi: 10.1093/hmg/ddt259. Epub 2013 Jun 4.
7
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Toxicology. 2013 Sep 6;311(1-2):69-77. doi: 10.1016/j.tox.2013.04.004. Epub 2013 Apr 11.
8
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