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两例肾移植受者发生的伴有单克隆IgG沉积的增殖性肾小球肾炎经利妥昔单抗治疗成功

Proliferative glomerulonephritis with monoclonal IgG deposits in two kidney allografts successfully treated with rituximab.

作者信息

Merhi Basma, Patel Nikunjkuma, Bayliss George, Henriksen Kammi J, Gohh Reginald

机构信息

Division of Kidney Disease and Hypertension, Department of Medicine, Rhode Island Hospital, Providence, RI, USA.

Alpert Medical School, Brown University, Providence, RI, USA.

出版信息

Clin Kidney J. 2017 Jun;10(3):405-410. doi: 10.1093/ckj/sfx001. Epub 2017 Mar 22.

DOI:10.1093/ckj/sfx001
PMID:28616219
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5466084/
Abstract

Proliferative glomerulonephritis with monoclonal immunoglobulin G deposit (PGNMID), a recently described pathologic entity in native kidneys, has been recognized in kidney transplant patients, where it can present as either recurrent or disease. There is no definitive treatment to date, in either population. Here, we present two cases of PGNMID in kidney allografts that illustrate the challenges of diagnostic approach and highlight the allograft outcome after treatment with rituximab as a potential treatment of this condition.

摘要

伴有单克隆免疫球蛋白G沉积的增殖性肾小球肾炎（PGNMID）是一种最近在原发性肾脏中被描述的病理实体，在肾移植患者中也已得到认识，在这些患者中它可表现为复发性或新发疾病。迄今为止，这两类患者群体均没有确切的治疗方法。在此，我们报告两例同种异体肾移植中发生PGNMID的病例，这些病例说明了诊断方法的挑战，并突出了利妥昔单抗作为这种疾病的一种潜在治疗方法进行治疗后的移植肾结局。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6067/5466084/c1282b019bcd/sfx001f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6067/5466084/c96f3f827442/sfx001f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6067/5466084/eabcdd8080aa/sfx001f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6067/5466084/86f5f8a61c15/sfx001f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6067/5466084/8a04915e527f/sfx001f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6067/5466084/167fe18a9c7d/sfx001f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6067/5466084/c1282b019bcd/sfx001f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6067/5466084/c96f3f827442/sfx001f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6067/5466084/eabcdd8080aa/sfx001f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6067/5466084/86f5f8a61c15/sfx001f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6067/5466084/8a04915e527f/sfx001f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6067/5466084/167fe18a9c7d/sfx001f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6067/5466084/c1282b019bcd/sfx001f6.jpg

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Curr Med Chem. 2024;31(41):6902-6908. doi: 10.2174/0109298673272183240108093135.
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