Faden A I, Molineaux C J, Rosenberger J G, Jacobs T P, Cox B M
Regul Pept. 1985 May;11(1):35-41. doi: 10.1016/0167-0115(85)90029-1.
Opiate antagonists, at high doses, have been shown to improve physiological variables and outcome after experimental spinal injury. Dynorphin appears to be unique amongst opioids in producing hindlimb paralysis after intrathecal injection. Taken together, these findings suggest a possible pathophysiological role for endogenous opioids, particularly dynorphin, in spinal injury. In the present studies we examined the relationship between changes in dynorphin immunoreactivity (Dyn-ir) in rat spinal cord after traumatic injury and the subsequent motor dysfunction. Trauma was associated with significantly increased Dyn-ir at the injury site, but not distant from the lesion. Dyn-ir was found elevated as early as 2 h and as late as 2 weeks after trauma, and was significantly correlated with the degree of injury. These data are consistent with the hypothesis that dynorphin systems may be involved in the secondary injury that follows spinal trauma.
阿片类拮抗剂在高剂量时已被证明可改善实验性脊髓损伤后的生理变量和预后。强啡肽在鞘内注射后能导致后肢麻痹，这在阿片类药物中似乎是独特的。综合来看，这些发现表明内源性阿片类物质，尤其是强啡肽，在脊髓损伤中可能具有病理生理作用。在本研究中，我们检测了创伤性损伤后大鼠脊髓中强啡肽免疫反应性（Dyn-ir）的变化与随后运动功能障碍之间的关系。创伤与损伤部位的Dyn-ir显著增加有关，但远离损伤部位则无此现象。创伤后最早在2小时以及最晚在2周时发现Dyn-ir升高，且与损伤程度显著相关。这些数据与强啡肽系统可能参与脊髓创伤后继发性损伤的假说一致。
