Bina Minou, Wyss Phillip, Song Xiaohui C
Purdue University, Department of Chemistry, West Lafayette, IN 47907, USA.
Information Technology at Purdue University, West Lafayette, IN 47907, USA.
Data Brief. 2017 May 28;13:202-207. doi: 10.1016/j.dib.2017.05.050. eCollection 2017 Aug.
While MLL1 activates gene expression in most tissues, ZFP57 represses transcription. MLL1 selectively interacts with a group of nonmethylated DNA sequences known as the MLL1 morphemes. ZFP57 associates with a methylated hexamer (ZFBS), dispersed in the genomic DNA segments known as Imprinted Control Regions (ICRs) and germline Differentially Methylated Regions (gDMRs), to maintain allele-specific gene repression. We have identified a set of composite DNA elements (ZFBS-Morph overlaps) that provides the sequence context of ZFBS in the canonical ICRs/gDMRs. This report provides tables listing the nucleotide sequences of the MLL1 morphemes and ZFBS-Morph overlaps. The report also offers links to the data repository at Purdue University, for downloading the positions of the MLL1 morphemes, the ZFP57 binding site, and the ZFBS-Morph overlaps in the mouse genome.
虽然MLL1在大多数组织中激活基因表达，但ZFP57抑制转录。MLL1选择性地与一组称为MLL1语素的非甲基化DNA序列相互作用。ZFP57与一个甲基化六聚体（ZFBS）结合，该六聚体分散在称为印记控制区（ICR）和种系差异甲基化区（gDMR）的基因组DNA片段中，以维持等位基因特异性基因抑制。我们已经鉴定出一组复合DNA元件（ZFBS-语素重叠），它们在典型的ICR/gDMR中提供了ZFBS的序列背景。本报告提供了列出MLL1语素和ZFBS-语素重叠的核苷酸序列的表格。该报告还提供了普渡大学数据存储库的链接，用于下载MLL1语素、ZFP57结合位点以及小鼠基因组中ZFBS-语素重叠的位置。
