Abd Thura T, Shafique Asim I, Yasir Hayder S, Seo Jung-Hee, George Richard T, Mittal Rajat, Lardo Albert C
Division of Cardiology, Department of Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
University of Maryland, College Park Campus, College Park, MD, United States.
Int J Cardiol Heart Vasc. 2016 May 18;12:11-14. doi: 10.1016/j.ijcha.2016.05.014. eCollection 2016 Sep.
Coronary computed tomography angiography (CCTA) is obtained using peripheral intravenous iodinated contrast agents (ICA) injection. There is continuing attempts to derive coronary physiological information like coronary blood flow (CBF) and/or fractional flow reserve from CCTA images. However, no data is available regarding the effect of peripheral intravenous injection of ICA on CBF.
A series of 4 experiments was performed using healthy mongrel dogs. All dogs underwent anesthesia and open thoracotomy with placement of ultrasound flowmeter to one of the coronary artery to provide real time absolute CBF measurements. Different infusion protocols of Isovue-370 and Visipaque-320 were injected into a peripheral vein. Similar doses of normal saline injection were performed to be used as controls. The effect of iodinated contrast media injection on absolute coronary blood flow was monitored and recorded.
Injection of normal saline in the peripheral vein did not produce any significant increase in CBF. Peripheral intravenous injection of ICA resulted in a consistent increase of 40-73% in absolute CBF as recorded 5 minutes post-contrast administration. The contrast effect starts about 30 seconds and peaks at about 2 minutepost-contrast injection then slowly fades away in the following 10-15 min. The increase in the CBF was dose related. There was greater increase in the CBF to 50 ml infusion compared to 25 ml infusion of both Visipaque and Isovue.
Peripheral venous administration of iodinated contrast-media in dogs results in a dose related, significant and prolonged increase in CBF.
冠状动脉计算机断层扫描血管造影（CCTA）是通过外周静脉注射碘化造影剂（ICA）获得的。人们一直在尝试从CCTA图像中获取冠状动脉生理信息，如冠状动脉血流（CBF）和/或血流储备分数。然而，关于外周静脉注射ICA对CBF的影响尚无数据。
使用健康杂种犬进行了一系列4个实验。所有犬均接受麻醉并开胸，将超声流量计置于一条冠状动脉上，以提供实时绝对CBF测量值。将不同的碘佛醇-370和威视派克-320输注方案注入外周静脉。注射相似剂量的生理盐水作为对照。监测并记录碘化造影剂注射对绝对冠状动脉血流的影响。
外周静脉注射生理盐水未使CBF产生任何显著增加。外周静脉注射ICA导致造影剂给药后5分钟记录的绝对CBF持续增加40%-73%。造影剂效果在造影剂注射后约30秒开始，在约2分钟时达到峰值，然后在接下来的10-15分钟内缓慢消退。CBF的增加与剂量相关。与威视派克和碘佛醇25ml输注相比，50ml输注时CBF增加更大。
犬外周静脉注射碘化造影剂导致CBF剂量相关、显著且持续的增加。
