Cagnasso Federica, Bruno Barbara, Bellino Claudio, Borrelli Antonio, Lippi Ilaria, Miniscalco Barbara, Roncone Silvia, Valazza Alberto, Zanatta Renato, Gianella Paola
Department of Veterinary Sciences, University of Turin, Largo P. Braccini 2, 10095 Grugliasco, Italy.
Department of Veterinary Sciences, University of Pisa, Via Livornese Lato Monte, 56121 Pisa, Italy.
Vet Sci. 2021 Jul 29;8(8):146. doi: 10.3390/vetsci8080146.
Intravenous iodinated contrast (IVIC) medium is routinely administered to dogs. Scattered information exists regarding the serum biochemical or urinary profiles associated with the administration of IVIC in dogs. The aim of the study was to describe, compare, and discuss from the perspective of previous studies the alterations in serum biochemical and urinary parameters before (T0) and within one week (T1) of the IVIC administration during routine computed tomography (CT) scan evaluation of 22 dogs. Mature dogs presenting for CT scan evaluation for preoperative oncology staging/surgical planning were included. T1 evaluation was performed within one week of IVIC administration. Statistically significant differences in serum total protein, albumin, chloride, calcium, and phosphorus concentrations, urine protein to creatinine ratio, and urine specific gravity were found between T1 and T0. At T1, the serum creatinine concentration was within reference ranges in all dogs but one. An increase in the urine protein to creatinine ratio was observed in four samples, one of which was non-proteinuric at T0. Changes in biochemistry and urine parameters between T0 and T1 were not considered clinically significant.
静脉注射碘化造影剂（IVIC）常用于犬类。关于犬类注射IVIC后的血清生化或尿液指标，仅有零散的信息。本研究旨在描述、比较并结合既往研究讨论22只犬在常规计算机断层扫描（CT）评估期间，于静脉注射IVIC前（T0）及注射后一周内（T1）血清生化和尿液参数的变化。纳入因术前肿瘤分期/手术规划而接受CT扫描评估的成年犬。T1评估在静脉注射IVIC后一周内进行。结果发现，T1与T0之间血清总蛋白、白蛋白、氯、钙和磷浓度、尿蛋白肌酐比及尿比重存在统计学显著差异。在T1时，除一只犬外，所有犬的血清肌酐浓度均在参考范围内。四个样本的尿蛋白肌酐比升高，其中一个样本在T0时无蛋白尿。T0与T1之间的生化和尿液参数变化不具有临床意义。
