Jones B D
Schizophr Bull. 1985;11(2):187-9. doi: 10.1093/schbul/11.2.187.
The author distinguishes between the putative neuroleptic-induced disorders of tardive dysmentia and supersensitivity psychosis. The distinction is made with regard to clinical features, response to pharmacological intervention, and proposed etiologies. It is suggested that tardive dysmentia is due not to dopaminergic supersensitivity but to some other neurotoxic phenomenon associated with the use of neuroleptic drugs. The possibility that cholinergic mechanisms are involved in the tardive dysmentia syndrome is examined. Finally, the potential for such drug-induced disorders to confuse diagnosis is highlighted.
作者区分了假定的抗精神病药物所致迟发性痴呆和超敏性精神病。这种区分是基于临床特征、对药物干预的反应以及提出的病因。有人认为迟发性痴呆并非由于多巴胺能超敏反应，而是与使用抗精神病药物相关的其他神经毒性现象所致。本文探讨了胆碱能机制参与迟发性痴呆综合征的可能性。最后，强调了此类药物所致疾病可能混淆诊断的潜在性。
