MNK通过反向调节TELO2与DEPTOR来控制mTORC1信号通路。
MNK inversely regulates TELO2 vs. DEPTOR to control mTORC1 signaling.
作者信息
Brown Michael C, Gromeier Matthias
机构信息
Department of Neurosurgery, Duke University Medical Center, Durham, NC, USA.
出版信息
Mol Cell Oncol. 2017 Mar 17;4(3):e1306010. doi: 10.1080/23723556.2017.1306010. eCollection 2017.
Abstract
mTORC1 is the major homeostatic nutrient sensor for the cell. As such, it is integrated into diverse signaling networks and co-factor interactions that determine its activity. Our recent work implicates the mTORC1 co-factor and PI3K-related Kinase (PIKK) stabilizer, TELO2, in regulating mTORC1 activity in a MAPK-Interacting Kinase (MNK) responsive manner during mitogenic stimulation of cancer cells and T cell activation.
摘要
mTORC1是细胞主要的稳态营养传感器。因此，它被整合到多种信号网络和辅助因子相互作用中，这些相互作用决定了它的活性。我们最近的研究表明，在癌细胞的有丝分裂刺激和T细胞激活过程中，mTORC1辅助因子和PI3K相关激酶（PIKK）稳定剂TELO2以一种对丝裂原活化蛋白激酶相互作用激酶（MNK）有反应的方式调节mTORC1活性。
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