Rao A, Cherian A, Onuora C U, Suvarnabai P C
Trop Geogr Med. 1985 Mar;37(1):11-4.
Forty six children suffering from Protein Energy Malnutrition (PEM) were classified according to the Wellcome classification. Their aspartate aminotransferase, alanine aminotransferase and gamma-glutamyl transferase were measured. Aspartate aminotransferase was raised in 20 patients (43.5%) and alanine aminotransferase was raised in 12 patients (26%). Y-glutamyl transferase was raised in only one patient suffering from marasmic kwashiorkor, who, in contrast to the rest of the patients had a marked rise in aminotransferases. The aminotransferase elevation correlated positively with a Severity Index calculated from height and weight retardation and serum albumin levels. It is suggested that the moderate rise in aminotransferases found in PEM is not due to damage to the liver. However, marked enzyme elevations can occur in a small minority of patients, suggestive of liver injury, probably caused by hepatotoxins.
46名患有蛋白质能量营养不良（PEM）的儿童根据韦尔科姆分类法进行了分类。检测了他们的天冬氨酸转氨酶、丙氨酸转氨酶和γ-谷氨酰转移酶。20名患者（43.5%）的天冬氨酸转氨酶升高，12名患者（26%）的丙氨酸转氨酶升高。只有一名患有消瘦型夸希奥科病的患者γ-谷氨酰转移酶升高，与其他患者相比，该患者的转氨酶显著升高。转氨酶升高与根据身高和体重发育迟缓以及血清白蛋白水平计算出的严重程度指数呈正相关。提示在PEM中发现的转氨酶中度升高并非由于肝脏损伤。然而，一小部分患者可能会出现显著的酶升高，提示可能由肝毒素引起的肝损伤。
