Echeverría de Carlos Ainara, Gómez de la Torre Ricardo, García Carus Enrique, Caminal Montero Luis, Bernardino Díaz López Jose, Suárez Casado Hector, Molinos Matin Luis, Tricas Aizpún Lourdes, Harding Stephen, Parker Antony R
a Immunology Department , Hospital Universitario Central de Asturias , Oviedo , Spain.
b Internal Medicine Department , Hospital Universitario Central de Asturias , Oviedo , Spain.
J Immunoassay Immunochem. 2017;38(5):505-513. doi: 10.1080/15321819.2017.1337641. Epub 2017 Jun 15.
The response to pneumococcal vaccination is assessed by measurement of antigen specific IgG only and is compromised in a number of antibody deficiencies. We measured the concentrations of Pneumococcal IgA and IgM in individuals with both normal and abnormal pneumococcal capsular polysaccharide (PCP) IgG concentrations. A higher number of individuals had abnormal pre-vaccination IgA and IgM concentrations below the lower limit of the normal range compared to the control group. Post vaccination a lower number of individuals had IgA and IgM concentrations below the upper limit of the normal range compared to the control group. Non responders had a higher percentage of individuals with a prior history of infection. In addition, individuals with a history of prior infection had lower pre- and post-vaccination concentrations of PCP IgG, IgA, and IgM. Post-vaccination IgA and IgM concentrations identified four groups of responses which correlated with prior history of infection. A higher percentage of individuals with abnormal PCP IgA and IgM concentrations had a history of prior infection compared to the percentage of individuals with normal concentrations. In individuals with an antibody deficiency, measurement of Pneumococcal IgA and IgM correlates with the number of individuals with prior history of infection.
仅通过测量抗原特异性IgG来评估对肺炎球菌疫苗的反应，并且在多种抗体缺陷情况下该反应会受到损害。我们测量了肺炎球菌荚膜多糖（PCP）IgG浓度正常和异常的个体中肺炎球菌IgA和IgM的浓度。与对照组相比，更多接种疫苗前的个体其IgA和IgM浓度异常且低于正常范围下限。接种疫苗后，与对照组相比，IgA和IgM浓度低于正常范围上限的个体数量减少。无反应者中曾有感染史的个体比例更高。此外，有既往感染史的个体接种疫苗前后PCP IgG、IgA和IgM的浓度较低。接种疫苗后的IgA和IgM浓度确定了四组与既往感染史相关的反应。与PCP IgA和IgM浓度正常的个体比例相比，PCP IgA和IgM浓度异常的个体中曾有感染史的比例更高。在抗体缺陷个体中，肺炎球菌IgA和IgM的测量结果与有既往感染史的个体数量相关。
