• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

通过与一个 {CoCl} 单元配位增强 [RuCp(PPh)(dmoPTA-1κP)] 的抗增殖活性：[RuCp(PPh)-μ-dmoPTA-1κP:2κN,N'-CoCl](OTf)·0.25HO 的合成、晶体结构和性质。

Enhancement of the antiproliferative activity of [RuCp(PPh)(dmoPTA-1κP)]via its coordination to one {CoCl} unit: synthesis, crystal structure and properties of [RuCp(PPh)-μ-dmoPTA-1κP:2κN,N'-CoCl](OTf)·0.25HO.

机构信息

Inorganic Chemistry Section, Chemistry Department, Faculty of Science, University of La Laguna, 38071 La Laguna, Tenerife, Spain.

出版信息

Dalton Trans. 2017 Jun 27;46(25):8009-8012. doi: 10.1039/c7dt01741c.

DOI:10.1039/c7dt01741c
PMID:28617514
Abstract

Synthesis, characterization and the antiproliferative activity of a new bimetallic complex [RuCp(PPh)-μ-dmoPTA-1κP:2kN,N'-CoCl]OTf·0.25HO are described. The stability of the complex was studied under air and N atmospheres and in CDCl, DMSO, water and the cell culture medium, at room temperature and 40 °C. The complex showed an enhanced antiproliferative activity (up to six-fold) when compared with its parent complex [RuCp(PPh)(HdmoPTA)] against human lung, cervix, breast, and colon solid tumor cell lines.

摘要

描述了一种新的双核配合物[RuCp(PPh)-μ-dmoPTA-1κP:2kN,N'-CoCl]OTf·0.25HO 的合成、表征和抗增殖活性。在空气和氮气气氛下以及在室温下和 40°C 下，在 CDCl、DMSO、水和细胞培养基中研究了配合物的稳定性。与母体配合物[RuCp(PPh)(HdmoPTA)]相比，该配合物对人肺、宫颈、乳腺和结肠实体肿瘤细胞系的增殖活性增强（高达六倍）。

相似文献

1
Enhancement of the antiproliferative activity of [RuCp(PPh)(dmoPTA-1κP)]via its coordination to one {CoCl} unit: synthesis, crystal structure and properties of [RuCp(PPh)-μ-dmoPTA-1κP:2κN,N'-CoCl](OTf)·0.25HO.通过与一个 {CoCl} 单元配位增强 [RuCp(PPh)(dmoPTA-1κP)] 的抗增殖活性：[RuCp(PPh)-μ-dmoPTA-1κP:2κN,N'-CoCl](OTf)·0.25HO 的合成、晶体结构和性质。
Dalton Trans. 2017 Jun 27;46(25):8009-8012. doi: 10.1039/c7dt01741c.
2
Synthesis and antiproliferative activity of the heterobimetallic complexes [RuClCp(PPh₃)-μ-dmoPTA-1κP:2κ²N,N'-MCl₂] (M = Co, Ni, Zn; dmoPTA = 3,7-dimethyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane).[RuClCp(PPh₃)-μ-dmoPTA-1κP:2κ²N,N'-MCl₂]（M = Co、Ni、Zn；dmoPTA = 3,7-二甲基-1,3,7-三氮杂-5-磷杂双环[3.3.1]壬烷）的杂双核配合物的合成及抗增殖活性。
Dalton Trans. 2013 Aug 21;42(31):11212-9. doi: 10.1039/c3dt50829c.
3
Insights into the κ-P,N Coordination of 1,3,5-Triaza-7-phosphaadamantane and Derivatives: κ-P,N-Heterometallic Complexes and a N Nuclear Magnetic Resonance Survey.对 1,3,5-三氮杂-7-磷杂金刚烷及其衍生物的 κ-P,N 配位的深入研究：κ-P,N-杂金属配合物和 N 核磁共振研究。
Inorg Chem. 2022 Apr 18;61(15):5779-5791. doi: 10.1021/acs.inorgchem.1c03831. Epub 2022 Apr 4.
4
Comparative study of [RuClCp(HdmoPTA-κP)(PPh3)][CF3SO3] and the heterobimetallic complexes [RuClCp(PPh3)-μ-dmoPTA-1κP:2κ2N,N'-M(acac-κ2O,O')2] (M=Co, Ni, Zn; dmoPTA=3,7-dimethyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane).[RuClCp(HdmoPTA-κP)(PPh3)][CF3SO3]与杂双核配合物[RuClCp(PPh3)-μ-dmoPTA-1κP:2κ2N,N'-M(acac-κ2O,O')2]（M=Co、Ni、Zn；dmoPTA=3，7-二甲基-1，3，7-三氮杂-5-磷杂双环[3.3.1]壬烷）的对比研究。
Dalton Trans. 2011 Apr 7;40(13):3237-44. doi: 10.1039/c0dt00571a. Epub 2011 Feb 21.
5
Synthesis and Antiproliferative Activity of [RuCp(PPh3)2(HdmoPTA)](OSO2CF3)2 (HdmoPTA = 3,7-H-3,7-Dimethyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane).[RuCp(PPh3)2(HdmoPTA)](OSO2CF3)2的合成及其抗增殖活性（HdmoPTA = 3,7-H-3,7-二甲基-1,3,7-三氮杂-5-磷杂双环[3.3.1]壬烷）
Inorg Chem. 2016 Aug 15;55(16):7820-2. doi: 10.1021/acs.inorgchem.6b01207. Epub 2016 Jul 27.
6
Water-soluble 3,7-dimethyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane (dmoPTA) as a polydentate ligand: synthesis of [RuClCp(PPh3)-mu-dmoPTA-1kappaP:2kappa2N,N'-Co(acac-kappa2O,O')2].H2O.水溶性3,7-二甲基-1,3,7-三氮杂-5-磷杂双环[3.3.1]壬烷（dmoPTA）作为多齿配体：[RuClCp(PPh3)-μ-dmoPTA-1κP:2κ2N,N'-Co(acac-κ2O,O')2].H2O的合成
Inorg Chem. 2008 Apr 7;47(7):2246-8. doi: 10.1021/ic702239w. Epub 2008 Mar 11.
7
Tetranuclear RuCu and RuNi complexes with nanomolar anticancer activity.具有纳摩尔抗癌活性的四核 RuCu 和 RuNi 配合物。
Dalton Trans. 2023 Jul 18;52(28):9541-9545. doi: 10.1039/d3dt01284k.
8
Evaluation of the Antiproliferative Properties of CpRu Complexes Containing N-Methylated Triazaphosphaadamantane Derivatives.含N-甲基化三氮杂磷金刚烷衍生物的CpRu配合物的抗增殖性能评估
Bioinorg Chem Appl. 2023 Sep 28;2023:6669394. doi: 10.1155/2023/6669394. eCollection 2023.
9
The Significant Influence of a Second Metal on the Antiproliferative Properties of the Complex [Ru(η -C H )(Cl )(dmoPTA)].第二种金属对配合物[Ru(η-C₆H₆)(Cl₂)(dmoPTA)]的抗增殖性能的显著影响
Chemistry. 2022 Jan 13;28(3):e202103048. doi: 10.1002/chem.202103048. Epub 2021 Dec 8.
10
Novel "ruthenium cyclopentadienyl"-peptide conjugate complexes against human FGFR(+) breast cancer.新型钌环戊二烯基-肽缀合物复合物抗人 FGFR(+)乳腺癌。
Dalton Trans. 2020 May 14;49(18):5974-5987. doi: 10.1039/d0dt00955e. Epub 2020 Apr 21.

引用本文的文献

1
Complexing Properties of Synthesized 1,3,5-Triaza-7-Phosphaadamantane Derivatives Towards Some Lanthanides and Transition Metal Cations With Significant Antimicrobial and Antioxidant Activities.合成的1,3,5-三氮杂-7-磷杂金刚烷衍生物对某些具有显著抗菌和抗氧化活性的镧系元素和过渡金属阳离子的络合性质
Dose Response. 2023 Nov 16;21(4):15593258231216274. doi: 10.1177/15593258231216274. eCollection 2023 Oct-Dec.
2
Evaluation of the Antiproliferative Properties of CpRu Complexes Containing N-Methylated Triazaphosphaadamantane Derivatives.含N-甲基化三氮杂磷金刚烷衍生物的CpRu配合物的抗增殖性能评估
Bioinorg Chem Appl. 2023 Sep 28;2023:6669394. doi: 10.1155/2023/6669394. eCollection 2023.
3
Insights into the κ-P,N Coordination of 1,3,5-Triaza-7-phosphaadamantane and Derivatives: κ-P,N-Heterometallic Complexes and a N Nuclear Magnetic Resonance Survey.
对 1,3,5-三氮杂-7-磷杂金刚烷及其衍生物的 κ-P,N 配位的深入研究：κ-P,N-杂金属配合物和 N 核磁共振研究。
Inorg Chem. 2022 Apr 18;61(15):5779-5791. doi: 10.1021/acs.inorgchem.1c03831. Epub 2022 Apr 4.
4
The Significant Influence of a Second Metal on the Antiproliferative Properties of the Complex [Ru(η -C H )(Cl )(dmoPTA)].第二种金属对配合物[Ru(η-C₆H₆)(Cl₂)(dmoPTA)]的抗增殖性能的显著影响
Chemistry. 2022 Jan 13;28(3):e202103048. doi: 10.1002/chem.202103048. Epub 2021 Dec 8.
5
Zinc Complexes with Nitrogen Donor Ligands as Anticancer Agents.含氮供体配体的锌配合物作为抗癌剂。
Molecules. 2020 Dec 9;25(24):5814. doi: 10.3390/molecules25245814.