Enhancement of the antiproliferative activity of [RuCp(PPh)(dmoPTA-1κP)]via its coordination to one {CoCl} unit: synthesis, crystal structure and properties of [RuCp(PPh)-μ-dmoPTA-1κP:2κN,N'-CoCl](OTf)·0.25HO.

Synthesis, characterization and the antiproliferative activity of a new bimetallic complex [RuCp(PPh)-μ-dmoPTA-1κP:2kN,N'-CoCl]OTf·0.25HO are described. The stability of the complex was studied under air and N atmospheres and in CDCl, DMSO, water and the cell culture medium, at room temperature and 40 °C. The complex showed an enhanced antiproliferative activity (up to six-fold) when compared with its parent complex [RuCp(PPh)(HdmoPTA)] against human lung, cervix, breast, and colon solid tumor cell lines.