具有纳摩尔抗癌活性的四核 RuCu 和 RuNi 配合物。
Tetranuclear RuCu and RuNi complexes with nanomolar anticancer activity.
机构信息
Área de Química Inorgánica-CIESOL, Universidad de Almería, 04120, Almería, Spain.
BioLab, Instituto Universitario de Bio-Orgánica "Antonio Gónzalez", Universidad de La Laguna, C/ Astrofísico Francisco Sánchez 2, 38071 La Laguna, Spain.
出版信息
Dalton Trans. 2023 Jul 18;52(28):9541-9545. doi: 10.1039/d3dt01284k.
Complexes {RuCp(PPh)-μ-dmoPTA-1κ:2κ-,'-CuCl}-μ-Cl-μ-OCH·(CHOH) (1) and {RuCp(PPh)-μ-dmoPTA-1κ:2κ-,'-NiCl}-μ-Cl-μ-OH (2) have been synthesized and characterized. Their antiproliferative activities were assessed against six human solid tumours showing nanomolar GI values. The effects of 1 and 2 on SW1573 cells colony formation, HeLa cells action mechanism and their interaction with the pBR322 DNA plasmid were evaluated.
{RuCp(PPh)-μ-dmoPTA-1κ:2κ-,'-CuCl}-μ-Cl-μ-OCH·(CHOH) (1) 和 {RuCp(PPh)-μ-dmoPTA-1κ:2κ-,'-NiCl}-μ-Cl-μ-OH (2) 已被合成并进行了表征。它们对六种人体实体瘤的抗增殖活性进行了评估，显示出纳摩尔的 GI 值。评估了 1 和 2 对 SW1573 细胞集落形成、HeLa 细胞作用机制及其与 pBR322 DNA 质粒相互作用的影响。
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