Department of Gerontology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou City, Henan Province, China.
Eur Rev Med Pharmacol Sci. 2017 May;21(10):2489-2498.
This paper researches on the protective effects of antioxidants on metabolic syndrome induced by thyroid dysfunction. While the role of Lipoic acid (LA), Resveratrol (R) and Quercetin (Q) are recognized, the mechanisms for their ameliorative effects are partially understood. Therefore, the objective of this study was to determine the prevalence of MS among university workers and to examine the relationship with thyroid function and mechanisms for protective effects of LA, Resveratrol and Quercetin on the heart, kidneys and lungs.
In the cross-sectional study, a total of 2273 university workers (1198 males and 1075 females) aged 22-60 participated. Anthropometric measurements (weight and height), blood pressure, fasting plasma glucose (FPG), lipids, liver and kidney function tests were carried out, thyroid stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3), total antioxidant capacity (T-AOC), lipid peroxidation products, malondialdehyde (MDA), advanced oxidation protein products (AOPP) and dityrosine levels were measured.
A further evaluation of oxidative stress markers in subclinical hypothyroidism (SCH) compared with normal thyroid function showed the differences. Among middle-aged men with SCH (n = 467), MDA concentrations (8.11 ± 1.39 nmol/ml) were significantly higher euthyroid controls (7.34 ± 1.31 nmol/ml; n = 190) while AOPP, dityrosine and T-AOC levels were not different.
It was demonstrated that prevalence of MS components was high. Targeting thyroid hormone restoration, inhibition of ACE and GSK3β via PI3K/AKT signaling pathway using LA, Resveratrol and Quercetin are potential novel therapeutic approaches for developing pharmaceuticals that could make significance in MS treatment.
本研究旨在探讨抗氧化剂对甲状腺功能障碍引起的代谢综合征的保护作用。尽管已经认识到硫辛酸（LA）、白藜芦醇（R）和槲皮素（Q）的作用，但它们的改善作用机制尚不完全清楚。因此，本研究的目的是确定大学生人群中 MS 的患病率，并研究其与甲状腺功能的关系，以及 LA、Resveratrol 和 Quercetin 对心脏、肾脏和肺部的保护作用机制。
在这项横断面研究中，共有 2273 名 22-60 岁的大学生（男性 1198 名，女性 1075 名）参与。进行了人体测量学测量（体重和身高）、血压、空腹血糖（FPG）、血脂、肝肾功能检查，测量了促甲状腺激素（TSH）、游离甲状腺素（FT4）、游离三碘甲状腺原氨酸（FT3）、总抗氧化能力（T-AOC）、脂质过氧化产物、丙二醛（MDA）、晚期氧化蛋白产物（AOPP）和二酪氨酸水平。
与正常甲状腺功能相比，进一步评估亚临床甲状腺功能减退症（SCH）中的氧化应激标志物显示出差异。在患有 SCH 的中年男性中（n = 467），MDA 浓度（8.11 ± 1.39 nmol/ml）明显高于甲状腺功能正常的对照组（n = 190，7.34 ± 1.31 nmol/ml），而 AOPP、二酪氨酸和 T-AOC 水平没有差异。
研究表明，MS 成分的患病率很高。针对甲状腺激素恢复，通过 PI3K/AKT 信号通路抑制 ACE 和 GSK3β，使用 LA、Resveratrol 和 Quercetin 可能是开发治疗 MS 的药物的潜在新治疗方法。
