促黄体生成素释放激素用于睾丸未完全降入阴囊。
Luteinising hormone releasing hormone for incomplete descent of the testis.
作者信息
Klidjian A M, Swift P G, Johnstone J M
出版信息
Arch Dis Child. 1985 Jun;60(6):568-71. doi: 10.1136/adc.60.6.568.
Abstract
Forty boys with 54 incompletely descended testes took part in a double blind, controlled trial of intranasal luteinising hormone releasing hormone. In the control (placebo) group of 18 boys there was no significant change in testicular descent and all required orchidopexy; in the 22 treated boys, however, 12 of 29 testes (42%) were found in a lower position. This study supports the idea that a trial of intranasal luteinising hormone releasing hormone (1200 micrograms/day for 28 days) will help clarify the need for orchidopexy in at least 30% of boys with incomplete descent of the testis, particularly those in whom the testes have emerged from the inguinal canal.
摘要
40名患有54个隐睾的男孩参与了一项关于鼻内促黄体生成素释放激素的双盲对照试验。在18名男孩的对照组（安慰剂组）中，睾丸下降情况无显著变化，所有患儿均需进行睾丸固定术；然而，在22名接受治疗的男孩中，29个睾丸中有12个（42%）位置下移。该研究支持这样一种观点，即鼻内促黄体生成素释放激素试验（每日1200微克，持续28天）将有助于明确至少30%的隐睾男孩，尤其是那些睾丸已从腹股沟管降出的男孩是否需要进行睾丸固定术。
相似文献
1
Luteinising hormone releasing hormone for incomplete descent of the testis.促黄体生成素释放激素用于睾丸未完全降入阴囊。
Arch Dis Child. 1985 Jun;60(6):568-71. doi: 10.1136/adc.60.6.568.
2
Treatment of cryptorchidism by intranasal synthetic luteinising-hormone releasing hormone. Results of a collaborative double-blind study.经鼻应用合成促黄体生成素释放激素治疗隐睾症。一项合作双盲研究的结果。
Lancet. 1977 Sep 10;2(8037):518-20. doi: 10.1016/s0140-6736(77)90661-4.
3
[Undescended testis treated by intranasal application of luteinizing hormone-releasing hormone (LH-RH)].
Ugeskr Laeger. 1991 Feb 25;153(9):640-3.
4
Luteinising hormone-releasing hormone nasal spray as therapy for undescended testicle.促黄体生成素释放激素鼻喷雾剂治疗隐睾症
Arch Dis Child. 1978 Mar;53(3):235-8. doi: 10.1136/adc.53.3.235.
5
Double-blind, placebo-controlled study of luteinising-hormone-releasing-hormone nasal spray in treatment of undescended testes.
Lancet. 1986 Apr 19;1(8486):876-80. doi: 10.1016/s0140-6736(86)90986-4.
6
A systematic review and meta-analysis of comparative studies assessing the efficacy of luteinizing hormone-releasing hormone therapy for children with cryptorchidism.一项评估促黄体生成素释放激素疗法对隐睾症患儿疗效的比较研究的系统评价和荟萃分析。
Int Urol Nephrol. 2016 May;48(5):635-44. doi: 10.1007/s11255-016-1235-x. Epub 2016 Feb 22.
7
LH-RH nasal spray treatment for cryptorchidism. A double-blind, placebo-controlled study.
Eur J Pediatr. 1987;146 Suppl 2:S35-7. doi: 10.1007/BF00452867.
8
Intranasal LH-RH treatment of cryptorchidism. A clinical trial and 5 years follow-up.
Eur J Pediatr. 1987;146 Suppl 2:S40-1. doi: 10.1007/BF00452869.
9
Intra- and inter-observer variability in the assessment of testicular descent.
Andrologia. 1987 Sep-Oct;19(5):585-90. doi: 10.1111/j.1439-0272.1987.tb01905.x.
10
Hormonal therapy of cryptorchidism. A randomized, double-blind study comparing human chorionic gonadotropin and gonadotropin-releasing hormone.隐睾症的激素治疗。一项比较人绒毛膜促性腺激素和促性腺激素释放激素的随机双盲研究。
N Engl J Med. 1986 Feb 20;314(8):466-70. doi: 10.1056/NEJM198602203140802.
引用本文的文献
1
Effect of adjunctive hormonal therapy on testicular descent and spermatogenic function among children with cryptorchidism: a systematic review and meta-analysis.辅助激素治疗对隐睾症患儿睾丸下降和生精功能的影响：系统评价和荟萃分析。
Hormones (Athens). 2021 Mar;20(1):119-129. doi: 10.1007/s42000-020-00244-4. Epub 2020 Oct 29.
2
A systematic review and meta-analysis of comparative studies assessing the efficacy of luteinizing hormone-releasing hormone therapy for children with cryptorchidism.一项评估促黄体生成素释放激素疗法对隐睾症患儿疗效的比较研究的系统评价和荟萃分析。
Int Urol Nephrol. 2016 May;48(5):635-44. doi: 10.1007/s11255-016-1235-x. Epub 2016 Feb 22.
3
Intranasal LH-RH treatment of cryptorchidism. A clinical trial and 5 years follow-up.
Eur J Pediatr. 1987;146 Suppl 2:S40-1. doi: 10.1007/BF00452869.
4
LH-RH nasal spray treatment for cryptorchidism. A double-blind, placebo-controlled study.
Eur J Pediatr. 1987;146 Suppl 2:S35-7. doi: 10.1007/BF00452867.
本文引用的文献
1
Fertility in cryptorchids.隐睾症患者的生育能力
Minn Med. 1951 Mar;34(3):216-7.
2
Maldescent of the testis.睾丸下降不全
Arch Dis Child. 1983 Nov;58(11):847-8. doi: 10.1136/adc.58.11.847.
3
Hormonal treatment of cryptorchidism.隐睾症的激素治疗
Horm Res. 1982;16(3):188-92. doi: 10.1159/000179501.
4
[Intranasal administration of the gonadotropin-releasing hormone (LH-RH) in the treatment of undescended testis].[鼻内给予促性腺激素释放激素（LH-RH）治疗隐睾]
Ugeskr Laeger. 1981 Jun 15;143(25):1595-7.
5
Effect of gonadotropin in cryptorchism.促性腺激素在隐睾症中的作用。
J Urol. 1969 Dec;102(6):793-5. doi: 10.1016/s0022-5347(17)62254-7.
6
Therapeutic effects of luteinizing hormone releasing hormone (LH-RH) in cryptorchidism.促黄体生成激素释放激素（LH-RH）治疗隐睾症的疗效。
Andrologia. 1974;6(3):197-201. doi: 10.1111/j.1439-0272.1974.tb01202.x.
7
Intranasal GnRH therapy of maldescended testes.
Horm Metab Res. 1975 Sep;7(5):440-1. doi: 10.1055/s-0028-1095673.
8
Treatment of cryptorchidism by intranasal synthetic luteinising-hormone releasing hormone. Results of a collaborative double-blind study.经鼻应用合成促黄体生成素释放激素治疗隐睾症。一项合作双盲研究的结果。
Lancet. 1977 Sep 10;2(8037):518-20. doi: 10.1016/s0140-6736(77)90661-4.
9
Treatment of cryptorchidism by synthetic luteinising-hormone-releasing hormone.用合成促黄体生成激素释放激素治疗隐睾症。
Lancet. 1977;2(8052-8053):1361. doi: 10.1016/s0140-6736(77)90413-5.
10
Treatment of cryptorchidism with pernasal gonadotropin-releasing hormone therapy.经鼻促性腺激素释放激素疗法治疗隐睾症
Fertil Steril. 1978 May;29(5):546-51. doi: 10.1016/s0015-0282(16)43283-8.
Zotero 插件