经鼻应用合成促黄体生成素释放激素治疗隐睾症。一项合作双盲研究的结果。

Treatment of cryptorchidism by intranasal synthetic luteinising-hormone releasing hormone. Results of a collaborative double-blind study.

作者信息

Illig R, Exner G U, Kollmann F, Kellerer K, Borkenstein M, Lunglmayr L, Kuber W, Prader A

机构信息

Department of Paediatrics, University of Zürich, Switzerland.

出版信息

Lancet. 1977 Sep 10;2(8037):518-20. doi: 10.1016/s0140-6736(77)90661-4.

DOI:10.1016/s0140-6736(77)90661-4

PMID:95729

Abstract

The effect of intranasal luteinising-hormone releasing hormone (L.H.R.H.) in 84 boys with unilateral or bilateral cryptorchidism was evaluated in a double-blind controlled trial. Boys with retractile testes were not studied. L.H.R.H. caused no side-effects; plasma antibodies to L.H.R.H. were never demonstrated. Four weeks' therapy with intranasal L.H.R.H. administered in six doses daily (1.2 mg/day) led to complete descent in 38% of a total of 61 testes, an improved position in 28%, and no response in 19%; 15% of testes were never palpated. After placebo the position of 25% of testes was improved; there was no response in 75% of a total of 51 testes. The success-rate seemed to be independent of age, but was related to the initial testicular position, with complete descent in only 11% of testes not previously palpated compared with 48% of testes found in the inguinal region.

摘要

在一项双盲对照试验中，评估了鼻内注射促黄体生成素释放激素（L.H.R.H.）对84名单侧或双侧隐睾男孩的疗效。未对睾丸回缩的男孩进行研究。L.H.R.H.未引起副作用；从未检测到针对L.H.R.H.的血浆抗体。每天分六剂（1.2毫克/天）进行四周的鼻内L.H.R.H.治疗，在总共61个睾丸中，38%完全下降，28%位置改善，19%无反应；15%的睾丸从未触及。使用安慰剂后，51个睾丸中75%无反应，25%位置改善。成功率似乎与年龄无关，但与初始睾丸位置有关，先前未触及的睾丸中只有11%完全下降，而腹股沟区发现的睾丸中这一比例为48%。